@inproceedings{11fff7de34a64fc8911c0efb34248af9,
title = "An integrated Medical CPS for early detection of paroxysmal sympathetic hyperactivity",
abstract = "Paroxysmal sympathetic hyperactivity (PSH) is an important clinical problem of severe traumatic brain injury (TBI) which incurs approximately 90% of all TBI-related costs. However, current detection approach is hampered by no consensus clinical diagnostic criteria, paroxysmal episode feature with complex manifestations, and already overloaded clinical activities. These limitations cause delayed recognitions which result in poor clinical outcomes. In this paper, we design an integrated Medical Cyber-Physical System (Medical CPS) for early detection of paroxysmal sympathetic hyperactivity patients. First, a formal model is proposed to describe clinical diagnostic criteria. With the formalized models employed, we implement an early detector and integrate it with revised medical device adapters into Medical CPS. Our system will monitor patient conditions automatically and continuously to relieve medical staff from the heavy burden of clinical activities and provide timely decision supports. Evaluations on 107 clinical cases extracted from medical publications demonstrate the effectiveness and the efficiency of our integrated system.",
keywords = "Early Detection, Medical Cyber-Physical System, Paroxysmal Sympathetic Hyperactivity",
author = "Zuxing Gu and Hong Song and Yu Jiang and Jeonghone Choi and Hongjiang He and Lui Sha and Ming Gu",
note = "The authors thank Andrew Ou, Jiangxiang Liu and Xiaoyu Song for the discussions and help in this work. This work is supported in part by NSF CNS 1329886, NSF CNS 1545002, ONR N00014-14-1-0717, NSFC 91218302, NSFC 61527812, National Science and Technology Major Project(No.2016ZX01038101), MIIT IT funds (Research and application of TCN key technologies) of China, and The National Key Technology RandD Program (No. 2015BAG14B01-02); 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016 ; Conference date: 15-12-2016 Through 18-12-2016",
year = "2017",
month = jan,
day = "17",
doi = "10.1109/BIBM.2016.7822630",
language = "English (US)",
series = "Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "818--822",
editor = "Kevin Burrage and Qian Zhu and Yunlong Liu and Tianhai Tian and Yadong Wang and Hu, {Xiaohua Tony} and Qinghua Jiang and Jiangning Song and Shinichi Morishita and Kevin Burrage and Guohua Wang",
booktitle = "Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016",
address = "United States",
}