Paroxysmal sympathetic hyperactivity (PSH) is an important clinical problem of severe traumatic brain injury (TBI) which incurs approximately 90% of all TBI-related costs. However, current detection approach is hampered by no consensus clinical diagnostic criteria, paroxysmal episode feature with complex manifestations, and already overloaded clinical activities. These limitations cause delayed recognitions which result in poor clinical outcomes. In this paper, we design an integrated Medical Cyber-Physical System (Medical CPS) for early detection of paroxysmal sympathetic hyperactivity patients. First, a formal model is proposed to describe clinical diagnostic criteria. With the formalized models employed, we implement an early detector and integrate it with revised medical device adapters into Medical CPS. Our system will monitor patient conditions automatically and continuously to relieve medical staff from the heavy burden of clinical activities and provide timely decision supports. Evaluations on 107 clinical cases extracted from medical publications demonstrate the effectiveness and the efficiency of our integrated system.