An integrated Medical CPS for early detection of paroxysmal sympathetic hyperactivity

Zuxing Gu, Hong Song, Yu Jiang, Jeonghone Choi, Hongjiang He, Lui Sha, Ming Gu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Paroxysmal sympathetic hyperactivity (PSH) is an important clinical problem of severe traumatic brain injury (TBI) which incurs approximately 90% of all TBI-related costs. However, current detection approach is hampered by no consensus clinical diagnostic criteria, paroxysmal episode feature with complex manifestations, and already overloaded clinical activities. These limitations cause delayed recognitions which result in poor clinical outcomes. In this paper, we design an integrated Medical Cyber-Physical System (Medical CPS) for early detection of paroxysmal sympathetic hyperactivity patients. First, a formal model is proposed to describe clinical diagnostic criteria. With the formalized models employed, we implement an early detector and integrate it with revised medical device adapters into Medical CPS. Our system will monitor patient conditions automatically and continuously to relieve medical staff from the heavy burden of clinical activities and provide timely decision supports. Evaluations on 107 clinical cases extracted from medical publications demonstrate the effectiveness and the efficiency of our integrated system.

Original languageEnglish (US)
Title of host publicationProceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016
EditorsKevin Burrage, Qian Zhu, Yunlong Liu, Tianhai Tian, Yadong Wang, Xiaohua Tony Hu, Qinghua Jiang, Jiangning Song, Shinichi Morishita, Kevin Burrage, Guohua Wang
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages818-822
Number of pages5
ISBN (Electronic)9781509016105
DOIs
StatePublished - Jan 17 2017
Event2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016 - Shenzhen, China
Duration: Dec 15 2016Dec 18 2016

Publication series

NameProceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016

Other

Other2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016
CountryChina
CityShenzhen
Period12/15/1612/18/16

Keywords

  • Early Detection
  • Medical Cyber-Physical System
  • Paroxysmal Sympathetic Hyperactivity

ASJC Scopus subject areas

  • Genetics
  • Medicine (miscellaneous)
  • Genetics(clinical)
  • Biochemistry, medical
  • Biochemistry
  • Molecular Medicine
  • Health Informatics

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  • Cite this

    Gu, Z., Song, H., Jiang, Y., Choi, J., He, H., Sha, L., & Gu, M. (2017). An integrated Medical CPS for early detection of paroxysmal sympathetic hyperactivity. In K. Burrage, Q. Zhu, Y. Liu, T. Tian, Y. Wang, X. T. Hu, Q. Jiang, J. Song, S. Morishita, K. Burrage, & G. Wang (Eds.), Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016 (pp. 818-822). [7822630] (Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIBM.2016.7822630