An in vitro model for preclinical testing of thrombogenicity of resorbable metallic stents

Emily K. Walker, Eric A. Nauman, Jean Paul Allain, Lia A. Stanciu

Research output: Contribution to journalArticle

Abstract

Vascular stents that can biodegrade and disappear in time have been reported as a promising solution to the problems of late-stent thrombosis and in-stent restenosis. Iron alloys in particular have many advantages in terms of cytocompatibility and mechanical properties. Despite mechanical behavior and biocompatibility studies, little attention has been given to the thrombogenic potential of these stents. This article presents the first study that aims to close this gap by addressing the hemocompatibility of resorbable iron-based alloys and composites in an in vitro porcine blood model. The investigated braided biodegradable stents included 99.95% pure Fe (50% cold worked), Fe35Mn alloy, Fe35Mn-25% ZM21 (ZM21 is 2% Zn, 0.5% Mn, balance Mg), Fe-25% Mg, and Fe-57% Mg. All stents were formed by braiding 127 μm diameter wires into stents with an outer diameter of 6.35 mm. Inflammatory reaction and thrombocyte activation were examined by assessment of β-thromboglobulin, thrombin-antithrombin complex, and polymorphonuclear elastase levels. The potential of Fe35Mn for use in vascular stenting is demonstrated by its exhibition of the least thrombogenic potential among tested materials. All bioresorbable Fe-Mn alloy compositions showed a reduced propensity towards platelet adhesion compared to 316L stainless steel, further indicating a general positive shift towards reduced thrombogenicity compared to traditional stents.

Original languageEnglish (US)
Pages (from-to)2118-2125
Number of pages8
JournalJournal of Biomedical Materials Research - Part A
Volume103
Issue number6
DOIs
StatePublished - Jun 1 2015

Fingerprint

Cytotoxic T-Lymphocytes
Stents
Anthralin
African horse sickness virus
Cape Verde
Aldicarb
Blood Stains
Peptidyl Transferases
Animal Structures
Abdominal Muscles
Baclofen
Traffic Accidents
Iron alloys
Blood
Wire
Composite materials
Platelets
Biocompatibility
Adhesion
Stainless steel

Keywords

  • biomaterials
  • cardiovascular device
  • medical device

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

Cite this

An in vitro model for preclinical testing of thrombogenicity of resorbable metallic stents. / Walker, Emily K.; Nauman, Eric A.; Allain, Jean Paul; Stanciu, Lia A.

In: Journal of Biomedical Materials Research - Part A, Vol. 103, No. 6, 01.06.2015, p. 2118-2125.

Research output: Contribution to journalArticle

Walker, Emily K.; Nauman, Eric A.; Allain, Jean Paul; Stanciu, Lia A. / An in vitro model for preclinical testing of thrombogenicity of resorbable metallic stents.

In: Journal of Biomedical Materials Research - Part A, Vol. 103, No. 6, 01.06.2015, p. 2118-2125.

Research output: Contribution to journalArticle

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