An experimental burn wound-healing study of non-thermal atmospheric pressure microplasma jet arrays

Ok Joo Lee, Hyung Woo Ju, Gilson Khang, Peter P. Sun, Jose Rivera, Jin Hoon Cho, Sung Jin Park, J. Gary Eden, Chan Hum Park

Research output: Contribution to journalArticlepeer-review


In contrast with a thermal plasma surgical instrument based on coagulative and ablative properties, low-temperature (non-thermal) non-equilibrium plasmas are known for novel medicinal effects on exposed tissue while minimizing undesirable tissue damage. In this study we demonstrated that arrays of non-thermal microplasma jet devices fabricated from a transparent polymer can efficiently inactivate fungi (Candida albicans) as well as bacteria (Escherichia coli), both in vitro and in vivo, and that this leads to a significant wound-healing effect. Microplasma jet arrays offer several advantages over conventional single-jet devices, including superior packing density, inherent scalability for larger treatment areas, unprecedented material flexibility in a plasma jet device, and the selective generation of medically relevant reactive species at higher plasma densities. The therapeutic effects of our multi-jet device were verified on second-degree burns in animal rat models. Reduction of the wound area and the histology of the wound after treatment have been investigated, and expression of interleukin (IL)-1α, -6 and -10 was verified to evaluate the healing effects. The consistent effectiveness of non-thermal plasma treatment has been observed especially in decreasing wound size and promoting re-epithelialization through collagen arrangement and the regulation of expression of inflammatory genes.

Original languageEnglish (US)
Pages (from-to)348-357
Number of pages10
JournalJournal of Tissue Engineering and Regenerative Medicine
Issue number4
StatePublished - Apr 1 2016


  • Biomedical
  • Burn
  • Device
  • Microplasma
  • Non-thermal
  • Wound

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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