An expeditious route to 7α-substituted estradiol derivatives

Rosanna Tedesco, John A. Katzenellenbogen, Elio Napolitano

Research output: Contribution to journalArticlepeer-review


6-Ketoestradiol derivatives are converted in 7α-alkyl substituted estradiol derivatives selectively by alkylation of the generated enolate followed by deoxygenation-deprotection with BF3·Et2O/Et3SiH.

Original languageEnglish (US)
Pages (from-to)7997-8000
Number of pages4
JournalTetrahedron Letters
Issue number46
StatePublished - Nov 17 1997

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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