TY - JOUR
T1 - An evaluation of the markers p53 and Ki-67 for their predictive value in prostate cancer
AU - Uzoaru, Ike
AU - Rubenstein, Marvin
AU - Mirochnik, Yelena
AU - Slobodskoy, Leonid
AU - Shaw, Michael
AU - Guinan, Patrick
PY - 1998/1
Y1 - 1998/1
N2 - Background and Objectives: p53 and Ki-67 are but two markers being evaluated for their predictive value in prostate cancer. The purpose of this study was to compare p53 and Ki-67 with age, stage, Gleason score, and ploidy for their prognostic abilities in prostate cancer. Methods: Prostate cancer specimens from 134 patients were immunohistochemically stained for p53 and Ki-67 expression and differences evaluated by SPSS analysis of variance (ANOVA) methods. The dependent variable was patient survival and the independent variables were age, stage, Gleason score, and ploidy. Results: In decreasing order of prediction of survival were stage (P < 0.001), Gleason score (P < 0.001), age (P = 0.1869), Ki-67 (P = 0.2284), p53 (P = 0.4282) and ploidy (P = 0.8141). Conclusion: It is concluded that stage and Gleason score are significant predictors of survival while p53, Ki-67, age and ploidy are not.
AB - Background and Objectives: p53 and Ki-67 are but two markers being evaluated for their predictive value in prostate cancer. The purpose of this study was to compare p53 and Ki-67 with age, stage, Gleason score, and ploidy for their prognostic abilities in prostate cancer. Methods: Prostate cancer specimens from 134 patients were immunohistochemically stained for p53 and Ki-67 expression and differences evaluated by SPSS analysis of variance (ANOVA) methods. The dependent variable was patient survival and the independent variables were age, stage, Gleason score, and ploidy. Results: In decreasing order of prediction of survival were stage (P < 0.001), Gleason score (P < 0.001), age (P = 0.1869), Ki-67 (P = 0.2284), p53 (P = 0.4282) and ploidy (P = 0.8141). Conclusion: It is concluded that stage and Gleason score are significant predictors of survival while p53, Ki-67, age and ploidy are not.
KW - Ki-67
KW - Predictive value
KW - Prognostic indicator
KW - Prostate cancer
KW - p53
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U2 - 10.1002/(SICI)1096-9098(199801)67:1<33::AID-JSO7>3.0.CO;2-N
DO - 10.1002/(SICI)1096-9098(199801)67:1<33::AID-JSO7>3.0.CO;2-N
M3 - Article
C2 - 9457254
AN - SCOPUS:0031929682
SN - 0022-4790
VL - 67
SP - 33
EP - 37
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
IS - 1
ER -