An evaluation of the markers p53 and Ki-67 for their predictive value in prostate cancer

Ike Uzoaru, Marvin Rubenstein, Yelena Mirochnik, Leonid Slobodskoy, Michael Shaw, Patrick Guinan

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Objectives: p53 and Ki-67 are but two markers being evaluated for their predictive value in prostate cancer. The purpose of this study was to compare p53 and Ki-67 with age, stage, Gleason score, and ploidy for their prognostic abilities in prostate cancer. Methods: Prostate cancer specimens from 134 patients were immunohistochemically stained for p53 and Ki-67 expression and differences evaluated by SPSS analysis of variance (ANOVA) methods. The dependent variable was patient survival and the independent variables were age, stage, Gleason score, and ploidy. Results: In decreasing order of prediction of survival were stage (P < 0.001), Gleason score (P < 0.001), age (P = 0.1869), Ki-67 (P = 0.2284), p53 (P = 0.4282) and ploidy (P = 0.8141). Conclusion: It is concluded that stage and Gleason score are significant predictors of survival while p53, Ki-67, age and ploidy are not.

Original languageEnglish (US)
Pages (from-to)33-37
Number of pages5
JournalJournal of Surgical Oncology
Volume67
Issue number1
DOIs
StatePublished - Jan 1998
Externally publishedYes

Keywords

  • Ki-67
  • p53
  • Predictive value
  • Prognostic indicator
  • Prostate cancer

ASJC Scopus subject areas

  • Surgery
  • Oncology

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