An evaluation of the genotoxic properties of herbicides following plant and animal activation

Michael Jacob Plewa, Elizabeth D. Wagner, Glenda J. Gentile, James M. Gentile

Research output: Contribution to journalArticle

Abstract

Commercial and technical grades of 11 herbicides and 13 combinations of commercial grade herbicides were evaluated for their genotoxic properties with Salmonella typhimurium, Saccharomyces cerevisiae directly and following plant and animal activation, or with Zea mays. The herbicides were related by their use in commercial corn (maize) production. Commercial grade formulations of each herbicide and combination of herbicides were also evaluated in situ with the pollen waxy locus assay of Z. mays. Eradicane and bifenox were negative in all assays. Alachlor, propachlor, procyazine and SD50093 (a formulation of cyanazine plus atrazine) were positive in one assay. Cyanazine, dicamba and metolachlor were positive in 2 assays. Atrazine, simazine and butylate were tested only in situ. Atrazine and simazine were positive and butylate was negative. Of the combinations of herbicides evaluated with the 3 genetic assays, alachlor plus bifenox and procyazine plus metolachlor were positive in 1 assay and metolachlor plus atrazine was positive in 2 assays. Of the combinations of herbicides evaluated only in situ, butylate plus atrazine, eradicane plus atrazine, eradicane plus cyanazine and metolachlor plus cyanazine were positive while butylate plus cyanazine was negative.

Original languageEnglish (US)
Pages (from-to)233-245
Number of pages13
JournalMutation Research/Genetic Toxicology
Volume136
Issue number3
DOIs
StatePublished - Jun 1984

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Atrazine
Herbicides
Assays
Animals
Chemical activation
Zea mays
Simazine
Dicamba
Salmonella
Salmonella typhimurium
Pollen
Yeast
Saccharomyces cerevisiae
cyanazine
butylate
metolachlor

ASJC Scopus subject areas

  • Toxicology
  • Genetics

Cite this

An evaluation of the genotoxic properties of herbicides following plant and animal activation. / Plewa, Michael Jacob; Wagner, Elizabeth D.; Gentile, Glenda J.; Gentile, James M.

In: Mutation Research/Genetic Toxicology, Vol. 136, No. 3, 06.1984, p. 233-245.

Research output: Contribution to journalArticle

Plewa, Michael Jacob ; Wagner, Elizabeth D. ; Gentile, Glenda J. ; Gentile, James M. / An evaluation of the genotoxic properties of herbicides following plant and animal activation. In: Mutation Research/Genetic Toxicology. 1984 ; Vol. 136, No. 3. pp. 233-245.
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