An ether-based peptide analog as c-AMP-dependent protein kinase inhibitor/substrate

Mengfei Ho, Amy Uhrin, Michelle Huang

Research output: Contribution to journalArticlepeer-review


Ether-based peptide analog L-EP contains an ether-linkage unit in place of the Ser-Leu-Gly unit of a PKA substrate, Kemptide. L-EP is a competitive inhibitor of Kemptide phosphorylation catalyzed by PKA with a Ki value of 120 μM. It also serves as a weak substrate of PKA with a Km value 25-fold higher and a Vmax value 3.5-fold lower than that of Kemptide.

Original languageEnglish (US)
Pages (from-to)553-556
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number4
StatePublished - Feb 24 1994
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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