An enhanced protein crosslink identification strategy using CID-cleavable chemical crosslinkers and LC/MS ⁿ analysis

Keyphrases

• Cleavable 100%
• Protein Cross-linking 100%
• Chemical Cross-linking 100%
• Liquid Chromatography-high Resolution Mass Spectrometry (LC-HRMS) 100%
• Identification Strategy 100%
• Protein System 66%
• Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) 33%
• Peptide Identification 33%
• Oligomeric Proteins 33%
• Crosslinking Agent 33%
• Database Search 33%
• Proline 33%
• Gas Phase 33%
• Published Data 33%
• Complex Mixtures 33%
• Mass Measurement Accuracy 33%
• Data Processing Algorithm 33%
• Data Dependency 33%
• Cleavable Linker 33%
• Complex Proteins 33%
• High Resolving Power 33%
• Peptide Selection 33%
• Multimeric Proteins 33%
• Fragmentation Pattern 33%

Chemistry

• Collision Induced Dissociation 100%
• Crosslinking 50%
• Data Processing 50%
• Complex Mixture 50%
• Proline 50%

Biochemistry, Genetics and Molecular Biology

• Cross-Link 100%
• Protein Complexes 20%
• Proline 20%
• Data Processing 20%