An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase

Gabrielle N. Thibodeaux, Wilfred A. van der Donk

Research output: Contribution to journalArticlepeer-review

Abstract

Phosphorylation is an abundant post-translational modification involved in a myriad of cell signaling pathways. Herein, we have engineered the class II lantipeptide synthetase ProcM to generate a variety of peptides containing O-phosphoserine (pSer) and O-phosphothreonine (pThr) residues, either in vitro or in vivo.

Original languageEnglish (US)
Pages (from-to)10615-10617
Number of pages3
JournalChemical Communications
Volume48
Issue number86
DOIs
StatePublished - Oct 3 2012

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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