@article{f949a585d96f4e38b4f99937bf0b475e,
title = "An Emerging Circuit Pharmacology of GABAA Receptors",
abstract = "In the past 20 years we have learned a great deal about GABAA receptor (GABAAR) subtypes, and which behaviors are regulated or which drug effects are mediated by each subtype. However, the question of where GABAARs involved in specific drug effects and behaviors are located in the brain remains largely unanswered. We review here recent studies taking a circuit pharmacology approach to investigate the functions of GABAAR subtypes in specific brain circuits controlling fear, anxiety, learning, memory, reward, addiction, and stress-related behaviors. The findings of these studies highlight the complexity of brain inhibitory systems and the importance of taking a subtype-, circuit-, and neuronal population-specific approach to develop future therapeutic strategies using cell type-specific drug delivery.",
keywords = "GABA receptor, addiction, anxiety, depression, hippocampus, memory",
author = "Elif Engin and Benham, {Rebecca S.} and Uwe Rudolph",
note = "Funding Information: E.E. is supported by award K01MH107787 from the National Institute of Mental Health, R.S.B. by a McLean Hospital Presidential Fellowship, and U.R. by award R01MH095905 from the National Institute of Mental Health, a NARSAD Distinguished Investigator Award (25623) from the Brain and Behavior Research Foundation as a P&S Fund Investigator, a grant from the Whitehall Foundation (2017-08-31), and a grant from the Harvard Brain Science Initiative Bipolar Disorder Seed Grant supported by Kent and Liz Dauten. Work reported in this review from the laboratory of the authors was also supported by award R01GM086448 from the National Institute of General Medical Sciences (to U.R.), R01MH080006 from the National Institute of Mental Health (to U.R.), and a NARSAD Young Investigator Grant ( 19266) from the Brain and Behavior Research Foundation to E.E. The funders played no role in the preparation of the manuscript. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",
year = "2018",
month = aug,
doi = "10.1016/j.tips.2018.04.003",
language = "English (US)",
volume = "39",
pages = "710--732",
journal = "Trends in Pharmacological Sciences",
issn = "0165-6147",
publisher = "Elsevier Limited",
number = "8",
}