An ultrasound exposimetry system was designed and constructed to expose rat embryos and fetuses to ultrasound. The unique feature of the exposure system is that it insonates pregnant rats which are not anesthetized or otherwise restrained. The rats were trained to float in a restricted area directly above the submerged ultrasound transducer. The water tank was designed to confine the floating rat to a 15-cm × 10-cm region while being exposed to ultrasound. The ultrasound transducer operating in either pulsed or continuous-wave (CW) mode is submerged below the animal and moved in a raster fashion to irradiate the entire abdominal area. Computer control of the exposure system and the ultrasound intensity levels allow for the experiments to be conducted in a blind fashion. Using a calibrated hydrophone, pressure waveforms are obtained from which the free-field ISPTA and ISPTP are calculated at the distance of the rat's abdomen.
|Original language||English (US)|
|Number of pages||4|
|Journal||Ultrasonics Symposium Proceedings|
|State||Published - 1990|
|Event||Proceedings of the IEEE 1990 Ultrasonics Symposium - Honolulu, HI, USA|
Duration: Dec 4 1990 → Dec 7 1990
ASJC Scopus subject areas