An assessment of a coupled three-state kinetic model for sodium conductance changes

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Abstract

The behavior of a coupled three-state kinetic scheme is examined to see if it might be a viable model for the conductance changes of sodium channels. It is found that for simulations of experiments which determine the properties of the Hodgkin-Huxley m and h gates, the three-state scheme performs approximately equivalently to the Hodgkin-Huxley model. In particular, the three-state scheme successfully simulates those experiments which the Hodgkin-Huxley model successfully simulates, but fails to simulate those newer voltage clamp experiments which give results anomalous to the H-H model. It is concluded that the three-state scheme is probably as good as the H-H model, but is not a viable successor to it.

Original languageEnglish (US)
Pages (from-to)291-301
Number of pages11
JournalBiophysical journal
Volume16
Issue number4
DOIs
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics

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