An Allosteric Binding Site on Sortilin Regulates the Trafficking of VLDL, PCSK9, and LDLR in Hepatocytes

Keyphrases

• Hepatocytes 100%
• Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) 100%
• LDL Receptor 100%
• Low-density Lipoprotein Receptor 100%
• Sortilin 100%
• Allosteric Binding Site 100%
• Low-density Lipoprotein 42%
• Apolipoprotein B (Apo B) 42%
• C-terminus 28%
• PIP3 28%
• Neurotensin 28%
• Molecular Dynamics Simulation 14%
• Lipids 14%
• Binding Site 14%
• Electrostatic Interaction 14%
• Plasma Membrane 14%
• Binding Affinity 14%
• Neuropeptides 14%
• Lipoproteins 14%
• Endocytosis 14%
• Cargo 14%
• Cellular Lipids 14%
• Multiple Effects 14%
• Lysosome 14%
• Lipid Homeostasis 14%
• Allosteric Regulators 14%
• Very-low-density Lipoprotein Secretion 14%
• Cargo Receptor 14%
• Subtilase 14%
• Low-affinity Interactions 14%

Biochemistry, Genetics and Molecular Biology

• Binding Site 100%
• Hepatocyte 100%
• Secretion (Process) 100%
• LDL Receptor 100%
• PCSK9 100%
• VLDL Receptor 100%
• Very Low-Density Lipoprotein 80%
• C-Terminus 40%
• Neurotensin 40%
• Dynamics 20%
• Cell Membrane 20%
• Lipid 20%
• Static Electricity 20%
• Eicosanoid Receptor 20%
• Binding Affinity 20%
• Neuropeptide 20%
• Endocytosis 20%
• Lysosome 20%
• Lipid Homeostasis 20%
• Phosphatidylinositol (3,4,5)-trisphosphate 20%
• Apolipoprotein B 20%
• Lipoprotein Secretion 20%
• Subtilase 20%