An African Swine Fever Virus Gene with Similarity to the T-Lymphocyte Surface Antigen CD2 Mediates Hemadsorption

M. V. Borca, G. F. Kutish, C. L. Afonso, P. Irusta, C. Carrillo, A. Brun, M. Sussman, D. L. Rock

Research output: Contribution to journalArticlepeer-review

Abstract

An open reading frame, LMW8-DR, in the African swine fever virus (ASFV) genome possesses striking similarity to the lymphocyte membrane antigen CD2. All characterized CD2 domains, including the amino-terminal signal sequence, IgV, hinge, IgC2, stalk, transmembrane, and proline-rich carboxy cytoplasmic domains, are highly conserved in the ASFV gene. Critical residues for the binding of the lymphocyte function-associated antigen (LFA-3) and CD59 and for T-cell activation are also partially conserved. LMW8-DR is actively transcribed in ASFV-infected swine macrophages and Vero cells at late times in the infection cycle and Vero and COS cells transiently expressing the LMW8-DR open reading frame hemadsorbed swine red blood cells. The structural and functional similarities of LMW8-DR to CD2, a protein that is involved in cell-cell adhesion and immune response modulation, suggest a possible role in the pathogenesis of ASFV infection.

Original languageEnglish (US)
Article number71146
Pages (from-to)463-468
Number of pages6
JournalVirology
Volume199
Issue number2
DOIs
StatePublished - Mar 1994
Externally publishedYes

ASJC Scopus subject areas

  • Virology

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