An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Esptein-Barr virus gene BHRF1

J. G. Neilan, Z. Lu, C. L. Afonso, G. F. Kutish, M. D. Sussman, D. L. Rock

Research output: Contribution to journalComment/debatepeer-review

Abstract

An open reading frame, LMW5-HL, in the African swine fever virus genome displays a high degree of similarity to the proto-oncogene bcl-2 and, to a lesser degree, the Epstein-Barr virus gene BHRF1. A highly conserved central region is found in all three proteins. LMW5-HL encodes a protein of 18 kDa that is present in infected porcine macrophages at both early and late times postinfection. The similarity of LMW5-HL to bcl-2 and BHRF1 suggests a role for it in cell maintenance during productive or persistent viral infection.

Original languageEnglish (US)
Pages (from-to)4391-4394
Number of pages4
JournalJournal of virology
Volume67
Issue number7
DOIs
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Fingerprint Dive into the research topics of 'An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Esptein-Barr virus gene BHRF1'. Together they form a unique fingerprint.

Cite this