Abstract
An open reading frame, LMW5-HL, in the African swine fever virus genome displays a high degree of similarity to the proto-oncogene bcl-2 and, to a lesser degree, the Epstein-Barr virus gene BHRF1. A highly conserved central region is found in all three proteins. LMW5-HL encodes a protein of 18 kDa that is present in infected porcine macrophages at both early and late times postinfection. The similarity of LMW5-HL to bcl-2 and BHRF1 suggests a role for it in cell maintenance during productive or persistent viral infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4391-4394 |
| Number of pages | 4 |
| Journal | Journal of virology |
| Volume | 67 |
| Issue number | 7 |
| DOIs |
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| State | Published - 1993 |
| Externally published | Yes |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology