An African swine fever virus Bcl-2 homolog, 5-HL, suppresses apoptotic cell death

C. L. Afonso, J. G. Neilan, G. F. Kutish, D. L. Rock

Research output: Contribution to journalArticlepeer-review

Abstract

Here, we show that the African swine fever virus 5-HL gene is a highly conserved viral gene and contains all known protein domains associated with Bcl-2 activity, including those involved with dimerization, mediating cell death, and protein-binding functions, and that its protein product, p21, suppresses apoptotic cell death in the mammalian lymphoid cell line FL5.12. Thus, 5-HL is a true functional viral member of the Bcl-2 gene family.

Original languageEnglish (US)
Pages (from-to)4858-4863
Number of pages6
JournalJournal of virology
Volume70
Issue number7
DOIs
StatePublished - Jun 27 1996
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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