Abstract
Sweet success: The classical approach to macrolide antibiotics involves a macrocyclization followed by the introduction of the carbohydrate residue(s). Now for the first time, a glycosylated seco-acid (see scheme, left) was cyclized to give an intermediate that was converted into a naturally occurring macrolide, as exemplified by the synthesis of erythromycin B (right).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3278-3281 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 42 |
| Issue number | 28 |
| DOIs | |
| State | Published - Jul 28 2003 |
| Externally published | Yes |
Keywords
- Asymmetric synthesis
- Cyclization
- Glycosylation
- Macrolactonization
- Natural products
- Total synthesis
ASJC Scopus subject areas
- Catalysis
- General Chemistry