Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2α and eEF2

Keyphrases

• Neural Activity 100%
• Phosphorylation 100%
• Translational Repression 100%
• Amyloid beta 100%
• Fragile X Mental Retardation 1 (FMR1) 100%
• EEF2 100%
• EIF2 100%
• Alzheimer's Disease 28%
• Cellular Stress Response 28%
• Novel Mechanism 14%
• Synapse 14%
• Neuronal Firing 14%
• Neural Plasticity 14%
• Cultured Primary Neurons 14%
• RNA-binding Protein 14%
• Fragile X Mental Retardation Protein 14%
• Indirect Mechanism 14%
• Phosphatase 14%
• Excitatory Synapse 14%
• Protein Phosphatase 2A (PP2A) 14%
• Fire Behavior 14%
• Translational Regulation 14%
• Most Common Cause 14%
• Protein Phosphatase 14%
• Amyloid-β Peptide 14%
• Causes of Dementia 14%
• Dementia with 14%

Biochemistry, Genetics and Molecular Biology

• Synapse 100%
• Amyloid Beta 100%
• Cellular Stress Response 100%
• Eukaryotic Initiation Factor 100%
• Eukaryotic Elongation Factors 100%
• Elongation Factor 2 100%
• Nerve Cell Plasticity 50%
• RNA-binding Protein 50%
• Phosphatase 50%
• Beta-Peptide 50%
• Phosphoprotein Phosphatase 50%
• Translational Regulation 50%
• Protein Phosphatase 1 50%

Neuroscience

• Synapse 100%
• Alzheimer's Disease 100%
• Beta Amyloid 100%
• Elongation Factor 2 100%
• Prothrombin 100%
• Cellular Stress Response 100%
• Fragile X Mental Retardation Protein 50%
• Amyloid Beta Protein 50%
• Phosphatase 50%
• RNA-binding Protein 50%
• Phosphoprotein Phosphatase 1 50%
• Phosphoprotein Phosphatase 2A 50%
• Translational Regulation 50%