Amygdala's involvement in facilitating associative learning-induced plasticity: A promiscuous role for the amygdala in memory acquisition

Lily S. Chau, Roberto Galvez

Research output: Contribution to journalReview articlepeer-review

Abstract

It is widely accepted that the amygdala plays a critical role in acquisition and consolidation o45 f fear-related memories. Some of the more widely employed behavioral paradigms that have assisted in solidifying the amygdala's role in fear-related memories are associative learning paradigms. With most associative learning tasks, a neutral conditioned stimulus (CS) is paired with a salient unconditioned stimulus (US) that elicits an unconditioned response (UR). After multiple CS-US pairings, the subject learns that the CS predicts the onset or delivery of the US, and thus elicits a learned conditioned response (CR). Most fear-related associative paradigms have suggested that an aspect of the fear association is stored in the amygdala; however, some fear-motivated associative paradigms suggest that the amygdala is not a site of storage, but rather facilitates consolidation in other brain regions. Based upon various learning theories, one of the most likely sites for storage of long-term memories is the neocortex. In support of these theories, findings from our laboratory, and others, have demonstrated that trace-conditioning, an associative paradigm where there is a separation in time between the CS and US, induces learning-specific neocortical plasticity. The following review will discuss the amygdala's involvement, either as a site of storage or facilitating storage in other brain regions such as the neocortex, in fear- and non-fear-motivated associative paradigms. In this review, we will discuss recent findings suggesting a broader role for the amygdala in increasing the saliency of behaviorally relevant information, thus facilitating acquisition for all forms of memory, both fear- and non-fear-related. This proposed promiscuous role of the amygdala in facilitating acquisition for all memories further suggests a potential role of the amygdala in general learning disabilities.

Original languageEnglish (US)
JournalFrontiers in Integrative Neuroscience
Issue numberSEPTEMBER
DOIs
StatePublished - Sep 22 2012

Keywords

  • Cerebellum
  • Eyeblink conditioning
  • Fear conditioning
  • Inhibitory avoidance
  • Neocortex
  • Pavlovian conditioning
  • Thalamic reticular nucleus

ASJC Scopus subject areas

  • Sensory Systems
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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