Amphotericin B derivatives with improved therapeutic index

Martin D. Burke; Stephen A Davis; Brice E. Uno; Justin Struble; Ian Dailey; Kaitlyn C. Gray; David M. Knapp; Pulin Wang; Nagarjuna Palyam

Amphotericin B derivatives with improved therapeutic index

Martin D. Burke (Inventor), Stephen A Davis (Inventor), Brice E. Uno (Inventor), Justin Struble (Inventor), Ian Dailey (Inventor), Kaitlyn C. Gray (Inventor), David M. Knapp (Inventor), Pulin Wang (Inventor), Nagarjuna Palyam (Inventor)

Research output: Patent

Abstract

Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Original language	English (US)
U.S. patent number	11970512
Filing date	9/2/21
State	Published - Apr 30 2024

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title = "Amphotericin B derivatives with improved therapeutic index",

abstract = "Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.",

author = "Burke, {Martin D.} and Davis, {Stephen A} and Uno, {Brice E.} and Justin Struble and Ian Dailey and Gray, {Kaitlyn C.} and Knapp, {David M.} and Pulin Wang and Nagarjuna Palyam",

year = "2024",

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day = "30",

language = "English (US)",

type = "Patent",

note = "11970512",

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TY - PAT

T1 - Amphotericin B derivatives with improved therapeutic index

AU - Burke, Martin D.

AU - Davis, Stephen A

AU - Uno, Brice E.

AU - Struble, Justin

AU - Dailey, Ian

AU - Gray, Kaitlyn C.

AU - Knapp, David M.

AU - Wang, Pulin

AU - Palyam, Nagarjuna

PY - 2024/4/30

Y1 - 2024/4/30

N2 - Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

AB - Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

M3 - Patent

M1 - 11970512

Y2 - 2021/09/02

ER -

Amphotericin B derivatives with improved therapeutic index

Abstract

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