Amphotericin B derivatives with improved therapeutic index

Justin Struble (Inventor), Martin D. Burke (Inventor), Ian Dailey (Inventor), Nagarjuna Palyam (Inventor), David M. Knapp (Inventor), Pulin Wang (Inventor), Stephen A Davis (Inventor), Brice E. Uno (Inventor), Kaitlyn C. Gray (Inventor)

Research output: Patent

Abstract

Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
Original languageEnglish (US)
U.S. patent number11117920
StatePublished - Sep 14 2021

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