Amphotericin B derivatives with improved therapeutic index

Justin Struble; Martin D Burke; Ian Dailey; Nagarjuna Palyam; David M Knapp; Pulin Wang; Stephen A Davis; Brice E Uno; Kaitlyn C Gray

Amphotericin B derivatives with improved therapeutic index

Justin Struble (Inventor), Martin D Burke (Inventor), Ian Dailey (Inventor), Nagarjuna Palyam (Inventor), David M Knapp (Inventor), Pulin Wang (Inventor), Stephen A Davis (Inventor), Brice E Uno (Inventor), Kaitlyn C Gray (Inventor)

Research output: Patent

Abstract

Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Original language	English (US)
U.S. patent number	10323057
State	Published - Jun 18 2019

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title = "Amphotericin B derivatives with improved therapeutic index",

abstract = "Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.",

author = "Justin Struble and Burke, {Martin D} and Ian Dailey and Nagarjuna Palyam and Knapp, {David M} and Pulin Wang and Davis, {Stephen A} and Uno, {Brice E} and Gray, {Kaitlyn C}",

year = "2019",

month = jun,

day = "18",

language = "English (US)",

type = "Patent",

note = "10323057",

}

TY - PAT

T1 - Amphotericin B derivatives with improved therapeutic index

AU - Struble, Justin

AU - Burke, Martin D

AU - Dailey, Ian

AU - Palyam, Nagarjuna

AU - Knapp, David M

AU - Wang, Pulin

AU - Davis, Stephen A

AU - Uno, Brice E

AU - Gray, Kaitlyn C

PY - 2019/6/18

Y1 - 2019/6/18

N2 - Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

AB - Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

M3 - Patent

M1 - 10323057

ER -

Amphotericin B derivatives with improved therapeutic index

Abstract

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