Amino acid toxicities of Escherichia coli that are prevented by leucyl-tRNA synthetase amino acid editing

Vrajesh A. Karkhanis; Anjali P. Mascarenhas; Susan A. Martinis

doi:10.1128/JB.01215-07

Amino acid toxicities of Escherichia coli that are prevented by leucyl-tRNA synthetase amino acid editing

Vrajesh A. Karkhanis, Anjali P. Mascarenhas, Susan A. Martinis

Research output: Contribution to journal › Article › peer-review

Abstract

Leucyl-tRNA synthetase (LeuRS) has evolved an editing function to clear misactivated amino acids. An Escherichia coli-based assay was established to identify amino acids that compromise the fidelity of LeuRS and translation. Multiple nonstandard as well as standard amino acids were toxic to the cell when LeuRS editing was inactivated.

Original language	English (US)
Pages (from-to)	8765-8768
Number of pages	4
Journal	Journal of bacteriology
Volume	189
Issue number	23
DOIs	https://doi.org/10.1128/JB.01215-07
State	Published - Dec 2007

ASJC Scopus subject areas

Microbiology
Molecular Biology

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10.1128/JB.01215-07

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abstract = "Leucyl-tRNA synthetase (LeuRS) has evolved an editing function to clear misactivated amino acids. An Escherichia coli-based assay was established to identify amino acids that compromise the fidelity of LeuRS and translation. Multiple nonstandard as well as standard amino acids were toxic to the cell when LeuRS editing was inactivated.",

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Amino acid toxicities of Escherichia coli that are prevented by leucyl-tRNA synthetase amino acid editing

Abstract

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