Amino acid toxicities of Escherichia coli that are prevented by leucyl-tRNA synthetase amino acid editing

Vrajesh A. Karkhanis, Anjali P. Mascarenhas, Susan A. Martinis

Research output: Contribution to journalArticle

Abstract

Leucyl-tRNA synthetase (LeuRS) has evolved an editing function to clear misactivated amino acids. An Escherichia coli-based assay was established to identify amino acids that compromise the fidelity of LeuRS and translation. Multiple nonstandard as well as standard amino acids were toxic to the cell when LeuRS editing was inactivated.

Original languageEnglish (US)
Pages (from-to)8765-8768
Number of pages4
JournalJournal of bacteriology
Volume189
Issue number23
DOIs
StatePublished - Dec 2007

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Amino acid toxicities of Escherichia coli that are prevented by leucyl-tRNA synthetase amino acid editing'. Together they form a unique fingerprint.

  • Cite this