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Amino-acid-dependent shift in tRNA synthetase editing mechanisms
Jaya Sarkar,
Susan A. Martinis
Biochemistry
Chemistry
Office of the Vice Chancellor for Research and Innovation
Biomedical and Translational Sciences
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Keyphrases
Amino Acids
100%
TRNA Synthetase
100%
Editing Activity
100%
Synthetase
60%
Post-transfer Editing
60%
Leucyl-tRNA Synthetase
60%
Methionine
40%
Leucine
40%
Noncognate
40%
Escherichia Coli
20%
Enzyme-mediated
20%
Transfer RNA (tRNA)
20%
Multiple Stages
20%
Hydrolytic Activity
20%
Aminoacyl-tRNA Synthetase
20%
Aminoacylation
20%
Proofreading Activity
20%
Adenylates
20%
Mistranslation
20%
Pre-editing
20%
Biochemistry, Genetics and Molecular Biology
Amino Acids
100%
Transfer RNA
100%
Enzyme
66%
Methionine
66%
Isoleucine
66%
Escherichia coli
33%
Hydrolase
33%
Aminoacyl tRNA Synthetase
33%
Adenosine Monophosphate
33%
Aminoacylation
33%
Immunology and Microbiology
Amino Acid
100%
Transfer RNA
100%
Methionine
66%
Isoleucine
66%
Escherichia coli
33%
Aminoacylation
33%
Chemistry
Amino Acid
100%
Transfer RNA
100%
Methionine
50%
Isoleucine
50%
hydrolytic
25%