TY - JOUR
T1 - Aluminum-binding serum proteins
T2 - desferrioxamine alters serum aluminum speciation
AU - Favarato, Mosè
AU - Mizzen, Craig A.
AU - Sutherland, May K.
AU - krishnan, Bhuma
AU - Kruck, Theodore P.A.
AU - McLachlan, Donald R.Crapper
PY - 1992/4/30
Y1 - 1992/4/30
N2 - The aluminum content of four size classes of protein (high and low molecular weight, transferrin albumin and a fraction provisionally termed albindin) in sera from healthy volunteers (group I) and from aluminum workers with normal (group II) and high (group III) total serum aluminum was compared using size exclusion chromatography and electrothermal atomic absorption spectroscopy. In the absence of any drug treatment the transferrin albumin fraction was the major carrier, containing 29% to 33% of the aluminum recovered, in all three subject groups. Desferrioxamine treatment of groups II and III significantly decreased the proportion of aluminum bound by albumin transferrin (P < 0.05 in group III) and increased that bound by albindin (P < 0.05 in groups II and III). The albindin fraction contained over 40% of the aluminum recovered from sera of group III subjects during desferrioxamine treatment. We conclude that the albindin fraction contains a protein or proteins that can form stable complexes with aluminum which may be important in preventing aluminum toxicity.
AB - The aluminum content of four size classes of protein (high and low molecular weight, transferrin albumin and a fraction provisionally termed albindin) in sera from healthy volunteers (group I) and from aluminum workers with normal (group II) and high (group III) total serum aluminum was compared using size exclusion chromatography and electrothermal atomic absorption spectroscopy. In the absence of any drug treatment the transferrin albumin fraction was the major carrier, containing 29% to 33% of the aluminum recovered, in all three subject groups. Desferrioxamine treatment of groups II and III significantly decreased the proportion of aluminum bound by albumin transferrin (P < 0.05 in group III) and increased that bound by albindin (P < 0.05 in groups II and III). The albindin fraction contained over 40% of the aluminum recovered from sera of group III subjects during desferrioxamine treatment. We conclude that the albindin fraction contains a protein or proteins that can form stable complexes with aluminum which may be important in preventing aluminum toxicity.
KW - Aluminum
KW - Aluminum-binding serum proteins
KW - Chelation therapy
KW - Desferrioxamine
KW - Serum proteins
KW - Size exclusion chromatography
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U2 - 10.1016/0009-8981(92)90149-K
DO - 10.1016/0009-8981(92)90149-K
M3 - Article
C2 - 1591866
AN - SCOPUS:0026585885
VL - 207
SP - 41
EP - 55
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
IS - 1-2
ER -