Alu elements within human mRNAs are probable microRNA targets

Neil R. Smalheiser, Vetle Ingvald Torvik

Research output: Contribution to journalShort survey

Abstract

Recently, we reported that four microRNAs show perfect complementarity with MIR/LINE-2 elements within human mRNAs. This finding raises the question of whether microRNAs might also target other genomic repeats and transposable elements. Here, we demonstrate that almost 30 human microRNAs exhibit typical short-seed complementarity with a specific site within Alu elements that is highly conserved within 3′ untranslated regions of human mRNAs. The results suggest that at least some Alu elements within human mRNAs serve as microRNA targets.

Original languageEnglish (US)
Pages (from-to)532-536
Number of pages5
JournalTrends in Genetics
Volume22
Issue number10
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

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Alu Elements
MicroRNAs
Messenger RNA
DNA Transposable Elements
3' Untranslated Regions
Seeds

ASJC Scopus subject areas

  • Genetics

Cite this

Alu elements within human mRNAs are probable microRNA targets. / Smalheiser, Neil R.; Torvik, Vetle Ingvald.

In: Trends in Genetics, Vol. 22, No. 10, 01.10.2006, p. 532-536.

Research output: Contribution to journalShort survey

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