TY - JOUR
T1 - Altered ventilatory responses to exercise testing in young adult men with obstructive sleep apnea
AU - Hargens, Trent A.
AU - Guill, Stephen G.
AU - Aron, Adrian
AU - Zedalis, Donald
AU - Gregg, John M.
AU - Nickols-Richardson, Sharon M.
AU - Herbert, William G.
N1 - Funding Information:
Respiratory gas exchange equipment for this research was provided by SensorMedics, Yorba Linda, CA, a Division of VIASYS Healthcare, Inc. Parts of this research were supported by a grant from the ResMed Foundation, La Jolla, CA, and ResMed Corporation, San Diego, CA. Research conducted in the Laboratory for Health and Exercise Science, Department of Human Nutrition, Foods and Exercise, on the campus of Virginia Polytechnic Institute and State University, Blacksburg, VA, and the Sleep Disorders Network of Southwest Virginia, Christiansburg, VA.
PY - 2009/7
Y1 - 2009/7
N2 - Background: Obstructive sleep apnea (OSA) is a disorder characterized by repetitive obstructions of the upper airway. Individuals with OSA experience intermittent hypoxia, hypercapnia, and arousals during sleep, resulting in increased sympathetic activation. Chemoreflex activation, arising from the resultant oscillatory disturbances in blood gases from OSA, exerts control over ventilation, and may induce increases in sympathetic vasoconstriction, contributing to increased long-term risks for hypertension (HTN) and cardiovascular disease (CVD). Methods: To evaluate whether OSA elicits exaggerated ventilatory responses to exercise in young men, 14 overweight men with OSA and 16 overweight men without OSA performed maximal ramping cycle ergometer exercise tests. Oxygen consumption (VO2), ventilation, (VE), ventilatory equivalents for oxygen (VE/VO2) and carbon dioxide (VE/VCO2), and VE/VCO2 slope were measured. Results: The VO2 response to exercise did not differ between groups. The VE, VE/VCO2, VE/VO2 were higher (p < 0.05, 0.002, and p < 0.02, respectively) in the OSA group across all workloads. The VE/VCO2 slope was greater in the OSA group (p < 0.05). The VE/VCO2 slope and AHI were significantly correlated (r = 0.56, p < 0.03). Thus, young, overweight men with OSA exhibit increased ventilatory responses to exercise when compared to overweight controls. This may reflect alterations in chemoreflex sensitivity, and contribute to increased sympathetic drive and HTN risk.
AB - Background: Obstructive sleep apnea (OSA) is a disorder characterized by repetitive obstructions of the upper airway. Individuals with OSA experience intermittent hypoxia, hypercapnia, and arousals during sleep, resulting in increased sympathetic activation. Chemoreflex activation, arising from the resultant oscillatory disturbances in blood gases from OSA, exerts control over ventilation, and may induce increases in sympathetic vasoconstriction, contributing to increased long-term risks for hypertension (HTN) and cardiovascular disease (CVD). Methods: To evaluate whether OSA elicits exaggerated ventilatory responses to exercise in young men, 14 overweight men with OSA and 16 overweight men without OSA performed maximal ramping cycle ergometer exercise tests. Oxygen consumption (VO2), ventilation, (VE), ventilatory equivalents for oxygen (VE/VO2) and carbon dioxide (VE/VCO2), and VE/VCO2 slope were measured. Results: The VO2 response to exercise did not differ between groups. The VE, VE/VCO2, VE/VO2 were higher (p < 0.05, 0.002, and p < 0.02, respectively) in the OSA group across all workloads. The VE/VCO2 slope was greater in the OSA group (p < 0.05). The VE/VCO2 slope and AHI were significantly correlated (r = 0.56, p < 0.03). Thus, young, overweight men with OSA exhibit increased ventilatory responses to exercise when compared to overweight controls. This may reflect alterations in chemoreflex sensitivity, and contribute to increased sympathetic drive and HTN risk.
KW - Chemoreceptors
KW - Exercise test
KW - OSA
KW - V/VCO
KW - Ventilation
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U2 - 10.1016/j.rmed.2009.01.010
DO - 10.1016/j.rmed.2009.01.010
M3 - Article
C2 - 19217270
AN - SCOPUS:67349287419
SN - 0954-6111
VL - 103
SP - 1063
EP - 1069
JO - British Journal of Tuberculosis and Diseases of the Chest
JF - British Journal of Tuberculosis and Diseases of the Chest
IS - 7
ER -