Alteration in Resting-State Brain Activity in Stroke Survivors after Repetitive Finger Stimulation

Dorothy He, William A. Sikora, Shirley A. James, Jordan N. Williamson, Louis V. Lepak, Carolyn F. Cheema, Evgeny Sidorov, Sheng Li, Yuan Yang

Research output: Contribution to journalArticlepeer-review


Objective This quasi-experimental study examined the effect of repetitive finger stimulation on brain activation in eight stroke and seven control subjects, measured by quantitative electroencephalogram. Methods We applied 5 mins of 2-Hz repetitive bilateral index finger transcutaneous electrical nerve stimulation and compared differences pre- and post-transcutaneous electrical nerve stimulation using quantitative electroencephalogram metrics delta/alpha ratio and delta-theta/alpha-beta ratio. Results Between-group differences before and after stimulation were significantly different in the delta/alpha ratio (z = -2.88, P = 0.0040) and the delta-theta/alpha-beta ratio variables (z = -3.90 with P < 0.0001). Significant decrease in the delta/alpha ratio and delta-theta/alpha-beta ratio variables after the transcutaneous electrical nerve stimulation was detected only in the stroke group (delta/alpha ratio diff = 3.87, P = 0.0211) (delta-theta/alpha-beta ratio diff = 1.19, P = 0.0074). Conclusions The decrease in quantitative electroencephalogram metrics in the stroke group may indicate improved brain activity after transcutaneous electrical nerve stimulation. This finding may pave the way for a future novel therapy based on transcutaneous electrical nerve stimulation and quantitative electroencephalogram measures to improve brain recovery after stroke.

Original languageEnglish (US)
Pages (from-to)395-400
Number of pages6
JournalAmerican Journal of Physical Medicine and Rehabilitation
Issue number5
StatePublished - May 2024


  • Finger Stimulation
  • Sensory Stimulation
  • Stroke
  • DAR
  • EEG

ASJC Scopus subject areas

  • Rehabilitation
  • Physical Therapy, Sports Therapy and Rehabilitation


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