Allylic C-H amination for the preparation of syn-1,3-amino alcohol motifs

Grant T. Rice, M. Christina White

Research output: Contribution to journalArticlepeer-review

Abstract

A highly selective and general Pd/sulfoxide-catalyzed allylic C-H amination reaction en route to syn-1,3-amino alcohol motifs is reported. Key to achieving this reactivity under mild conditions is the use of electron-deficient N-nosyl carbamate nucleophiles that are thought to promote functionalization by furnishing higher concentrations of anionic species in situ. The reaction is shown to be orthogonal to classical C-C bond-forming/-reduction sequences as well as nitrene-based C-H amination methods.

Original languageEnglish (US)
Pages (from-to)11707-11711
Number of pages5
JournalJournal of the American Chemical Society
Volume131
Issue number33
DOIs
StatePublished - Aug 26 2009

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint Dive into the research topics of 'Allylic C-H amination for the preparation of syn-1,3-amino alcohol motifs'. Together they form a unique fingerprint.

Cite this