Abstract
A highly selective and general Pd/sulfoxide-catalyzed allylic C-H amination reaction en route to syn-1,3-amino alcohol motifs is reported. Key to achieving this reactivity under mild conditions is the use of electron-deficient N-nosyl carbamate nucleophiles that are thought to promote functionalization by furnishing higher concentrations of anionic species in situ. The reaction is shown to be orthogonal to classical C-C bond-forming/-reduction sequences as well as nitrene-based C-H amination methods.
Original language | English (US) |
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Pages (from-to) | 11707-11711 |
Number of pages | 5 |
Journal | Journal of the American Chemical Society |
Volume | 131 |
Issue number | 33 |
DOIs | |
State | Published - Aug 26 2009 |
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry