Allosteric control of ribozyme catalysis by using DNA constraints

Elena Zelin, Scott K. Silverman

Research output: Contribution to journalArticle

Abstract

Strings attached. Covalent attachment of two DNA strands to RNA enabled allosteric control of hammerhead ribozyme catalysis by formation of a double-stranded DNA constraint, as illustrated in the figure. The constraint acted by disrupting RNA tertiary structure while leaving the secondary structure essentially intact. (Figure Presented)

Original languageEnglish (US)
Pages (from-to)1907-1911
Number of pages5
JournalChemBioChem
Volume8
Issue number16
DOIs
StatePublished - Nov 5 2007

Keywords

  • DNA constraints macromolecular folding
  • Deoxyribozymes
  • RNA structures
  • Ribozymes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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