Abstract
Strings attached. Covalent attachment of two DNA strands to RNA enabled allosteric control of hammerhead ribozyme catalysis by formation of a double-stranded DNA constraint, as illustrated in the figure. The constraint acted by disrupting RNA tertiary structure while leaving the secondary structure essentially intact. (Figure Presented)
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1907-1911 |
| Number of pages | 5 |
| Journal | ChemBioChem |
| Volume | 8 |
| Issue number | 16 |
| DOIs | |
| State | Published - Nov 5 2007 |
Keywords
- DNA constraints macromolecular folding
- Deoxyribozymes
- RNA structures
- Ribozymes
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Organic Chemistry