Allosteric control of ribozyme catalysis by using DNA constraints

Elena Zelin, Scott K Silverman

Research output: Contribution to journalArticle

Abstract

Strings attached. Covalent attachment of two DNA strands to RNA enabled allosteric control of hammerhead ribozyme catalysis by formation of a double-stranded DNA constraint, as illustrated in the figure. The constraint acted by disrupting RNA tertiary structure while leaving the secondary structure essentially intact. (Figure Presented)

Original languageEnglish (US)
Pages (from-to)1907-1911
Number of pages5
JournalChemBioChem
Volume8
Issue number16
DOIs
StatePublished - Nov 5 2007

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Catalytic RNA
Catalysis
RNA
DNA
hammerhead ribozyme

Keywords

  • DNA constraints macromolecular folding
  • Deoxyribozymes
  • RNA structures
  • Ribozymes

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Allosteric control of ribozyme catalysis by using DNA constraints. / Zelin, Elena; Silverman, Scott K.

In: ChemBioChem, Vol. 8, No. 16, 05.11.2007, p. 1907-1911.

Research output: Contribution to journalArticle

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