@article{7aea5af09c964a729aee4ced49d6a61c,
title = "Albumin as a {"}trojan Horse{"} for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting",
abstract = "Although polymeric nanoconjugates (NCs) hold great promise for the treatment of cancer patients, their clinical utility has been hindered by the lack of efficient delivery of therapeutics to targeted tumor sites. Here, we describe an albumin-functionalized polymeric NC (Alb-NC) capable of crossing the endothelium barrier through a caveolae-mediated transcytosis pathway to better target cancer. The Alb-NC is prepared by nanoprecipitation of doxorubicin (Doxo) conjugates of poly(phenyl O-carboxyanhydrides) bearing aromatic albumin-binding domains followed by subsequent surface decoration of albumin. The administration of Alb-NCs into mice bearing MCF-7 human breast cancer xenografts with limited tumor vascular permeability resulted in markedly increased tumor accumulation and anti-tumor efficacy compared to their conventional counterpart PEGylated NCs (PEG-NCs). The Alb-NC provides a simple, low-cost and broadly applicable strategy to improve the cancer targeting efficiency and therapeutic effectiveness of polymeric nanomedicine.",
author = "Qian Yin and Li Tang and Kaimin Cai and Xujuan Yang and Lichen Yin and Yanfeng Zhang and Dobrucki, {Lawrence W.} and Helferich, {William G.} and Fan, {Timothy M.} and Jianjun Cheng",
note = "Funding Information: J. C. acknowledges support from the NIH (1R01CA207584 and 1R21CA198684). Q. Y., L. T. and K. C. were funded at the University of Illinois at Urbana-Champaign from the NIH National Cancer Institute Alliance for Nanotechnology in Cancer 'Midwest Cancer Nanotechnology Training Centre' Grant R25 CA154015A. Q. Y. and K. C. acknowledge the Beckman Institute Graduate Fellowship support at the University of Illinois at UrbanaChampaign. We thank Dr John King in Prof. Steve Granick's group for his help with FCS measurements. We are thankful to Dr Xinying Zong for her help with SDS-PAGE analysis. We thank Ms Catherine Yao for drawing the 3D pictures. Funding Information: J. C. acknowledges support from the NIH (1R01CA207584 and 1R21CA198684). Q. Y., L. T. and K. C. were funded at the University of Illinois at Urbana-Champaign from the NIH National Cancer Institute Alliance for Nanotechnology in Cancer {\textquoteleft}Midwest Cancer Nanotechnology Training Centre{\textquoteright} Grant R25 CA154015A. Q. Y. and K. C. acknowledge the Beckman Institute Graduate Fellowship support at the University of Illinois at Urbana–Champaign. We thank Dr John King in Prof. Steve Granick{\textquoteright}s group for his help with FCS measurements. We are thankful to Dr Xinying Zong for her help with SDS-PAGE analysis. We thank Ms Catherine Yao for drawing the 3D pictures. Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",
year = "2018",
month = may,
doi = "10.1039/c8bm00149a",
language = "English (US)",
volume = "6",
pages = "1189--1200",
journal = "Biomaterials Science",
issn = "2047-4830",
publisher = "Royal Society of Chemistry",
number = "5",
}