Alaskan bog blueberry (Vaccinium uliginosum) extract as an innovative topical approach to prevent uv-induced skin damage

Erika Pambianchi, Zachary Hagenberg, Alessandra Pecorelli, Mary Grace, Jean Philippe Therrien, Mary Ann Lila, Giuseppe Valacchi

Research output: Contribution to journalArticlepeer-review


Our body is continuously exposed to various exogenous aggressors, and, in particular, the skin represents the main target for outdoor stressors, including ultraviolet (UV) radiation. UV exposure is well-known to be associated with the development/worsening of extrinsic photoaging and a multitude of skin conditions. Considering the role of photoprotection in skin health, the research of natural photoprotective molecules becomes of great importance. Therefore, in this work we wanted to evaluate the beneficial protective effects of ripe berries of Vaccinium uliginosum (Alaska bog blueberry (BB)) extract (100 µg/mL) for preventing the cutaneous oxidative, inflammatory, and structural damage induced by exposure to 200 mJ of UVA/UVB radiation. We observed that the topical application of BB extract on human ex vivo skin explants averted the UV-induced cutaneous OxInflammatory phenomenon by quenching the increase in the oxidative and inflammatory marker levels, such as 4-hydroxynonenal (4HNE), heme-oxygenase-1 (HO-1), cyclooxygenase-2 (COX2), and aryl hydrocarbon receptor (AhR); as well as by counteracting the loss of structural proteins (filaggrin and involucrin) induced by UV radiation. Our data propose the use of a topical application of Alaska bog blueberry extract as a natural and valuable approach to ensure photoprotection against UV-induced skin damage and premature aging.

Original languageEnglish (US)
Article number112
Issue number4
StatePublished - Dec 2021
Externally publishedYes


  • Antioxidant
  • Cosmeceuticals
  • Environmental stressor
  • Inflammation
  • OxInflammation
  • Oxidation
  • Phytochemicals

ASJC Scopus subject areas

  • Surgery
  • Chemical Engineering (miscellaneous)
  • Aging
  • Pharmaceutical Science
  • Dermatology


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