Akkermansia muciniphila-A Potential Next-generation Probiotic for Non-alcoholic Fatty Liver Disease

Goutam Banerjee, Suraya R. Papri, Sanjaya K. Satapathy, Pratik Banerjee

Research output: Contribution to journalShort surveypeer-review

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver conditions, and its growing prevalence is a serious concern worldwide, especially in Western countries. Researchers have pointed out several genetic mutations associated with NAFLD; however, the imbalance of the gut microbial community also plays a critical role in the progression of NAFLD. Due to the lack of approved medicine, probiotics gain special attention in controlling metabolic disorders like NAFLD. Among these probiotics, Akkermansia muciniphila (a member of natural gut microflora) is considered one of the most efficient and important bacterium in maintaining gut health, energy homeostasis, and lipid metabolism. In this perspective, we discussed the probable molecular mechanism of A. muciniphila in controlling the progression of NAFLD and restoring liver health. The therapeutic potential of A. muciniphila in NAFLD has been tested primarily on animal mod-els, and thus, more randomized human trials should be conducted to prove its efficacy.

Original languageEnglish (US)
Pages (from-to)426-433
Number of pages8
JournalCurrent Pharmaceutical Biotechnology
Volume25
Issue number4
DOIs
StatePublished - 2024

Keywords

  • Akkermansia muciniphila
  • energy homeostasis
  • gut health
  • gut microbiota
  • Nonalcoholic fatty liver disease
  • probiotics

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

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