Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation

Jae Sung You, Jie Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Sarcopenia, or age-related skeletal muscle atrophy and weakness, imposes significant clinical and economic burdens on affected patients and societies. Neurological degeneration, such as motoneuron death, has been recognized as a key contributor to sarcopenia. However, little is known about how aged/sarcopenic muscle adapts to this denervation stress. Here, we show that mice at 27months of age exhibit clear signs of sarcopenia but no accelerated denervation-induced muscle atrophy when compared to 8-month-old mice. Surprisingly, aging lends unique atrophy resistance to tibialis anteria muscle, accompanied by an increase in the cascade of mammalian target of rapamycin complex 1 (mTORC1)-independent anabolic events involving Akt signaling, rRNA biogenesis, and protein synthesis during denervation. These results expand our understanding of age-dependent stress responses and may help develop better countermeasures to sarcopenia.

Original languageEnglish (US)
Article number779547
JournalFrontiers in Physiology
Volume12
DOIs
StatePublished - Nov 30 2021

Keywords

  • Akt
  • aging
  • denervation
  • mTORC1
  • muscle
  • protein synthesis
  • rRNA

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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