Age-related ventricular-vascular coupling during acute inflammation in humans

Effect of physical activity

Abbi D. Lane, Rebecca M. Kappus, Kanokwan Bunsawat, Sushant M. Ranadive, Huimin Yan, Shane Phillips, Tracy Baynard, Jeffrey A. Woods, Robert Motl, Bo Fernhall

Research output: Contribution to journalArticle

Abstract

Background: Aging is commonly accompanied by increased arterial and ventricular stiffness (determined by arterial elastance (Ea) and ventricular elastance (Elv)), augmented ventricular-vascular coupling ratios (Ea/Elv) and systemic inflammation. Acute inflammation may impact ventricular-vascular coupling and predispose older adults to cardiovascular events. However, physically active older adults have more compliant large arteries and left ventricles and lower inflammation than sedentary older adults. We hypothesized that acute inflammation would alter Ea, Elv, and Ea/Elv more in older versus younger adults but that higher levels of physical activity would attenuate inflammation-induced changes. Methods: End-systolic and central blood pressures were obtained using applanation tonometry before and at 24 and 48 h post-influenza vaccination in 24 older and 38 younger adults. Ultrasonography was used to measure ventricular volumes and other indices of cardiac performance. Physical activity was measured with accelerometry. Results: Ea and Ea/Elv were maintained (p > 0.05), but Elv was reduced (p < 0.05) 24 h post-inflammation. Other indices of systolic performance were reduced in older but not younger adults; diastolic performance was attenuated in both groups 24 h post-inflammation (p < 0.05 for all). Older, but not younger, adults decreased central pressure during inflammation (p < 0.05). When controlled for age, physical activity was not related to the inflammation-induced changes in elastance (p > 0.05) except in the most active group of seniors (p < 0.05). Conclusions: Aging did not affect the elastance responses but did affect central blood pressure and other ventricular systolic responses to acute inflammation. Aging, not physical activity, appears to modulate cardiovascular responses to acute inflammation, except in the most active older adults.

Original languageEnglish (US)
Pages (from-to)904-911
Number of pages8
JournalEuropean Journal of Preventive Cardiology
Volume22
Issue number7
DOIs
StatePublished - Jul 9 2015

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Blood Vessels
Exercise
Inflammation
Young Adult
Accelerometry
Blood Pressure
Vascular Stiffness
Manometry
Human Influenza
Heart Ventricles
Ultrasonography
Vaccination
Arteries

Keywords

  • Inflammation
  • blood pressure
  • ventricular function

ASJC Scopus subject areas

  • Epidemiology
  • Cardiology and Cardiovascular Medicine

Cite this

Lane, A. D., Kappus, R. M., Bunsawat, K., Ranadive, S. M., Yan, H., Phillips, S., ... Fernhall, B. (2015). Age-related ventricular-vascular coupling during acute inflammation in humans: Effect of physical activity. European Journal of Preventive Cardiology, 22(7), 904-911. https://doi.org/10.1177/2047487314542056

Age-related ventricular-vascular coupling during acute inflammation in humans : Effect of physical activity. / Lane, Abbi D.; Kappus, Rebecca M.; Bunsawat, Kanokwan; Ranadive, Sushant M.; Yan, Huimin; Phillips, Shane; Baynard, Tracy; Woods, Jeffrey A.; Motl, Robert; Fernhall, Bo.

In: European Journal of Preventive Cardiology, Vol. 22, No. 7, 09.07.2015, p. 904-911.

Research output: Contribution to journalArticle

Lane, AD, Kappus, RM, Bunsawat, K, Ranadive, SM, Yan, H, Phillips, S, Baynard, T, Woods, JA, Motl, R & Fernhall, B 2015, 'Age-related ventricular-vascular coupling during acute inflammation in humans: Effect of physical activity', European Journal of Preventive Cardiology, vol. 22, no. 7, pp. 904-911. https://doi.org/10.1177/2047487314542056
Lane, Abbi D. ; Kappus, Rebecca M. ; Bunsawat, Kanokwan ; Ranadive, Sushant M. ; Yan, Huimin ; Phillips, Shane ; Baynard, Tracy ; Woods, Jeffrey A. ; Motl, Robert ; Fernhall, Bo. / Age-related ventricular-vascular coupling during acute inflammation in humans : Effect of physical activity. In: European Journal of Preventive Cardiology. 2015 ; Vol. 22, No. 7. pp. 904-911.
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abstract = "Background: Aging is commonly accompanied by increased arterial and ventricular stiffness (determined by arterial elastance (Ea) and ventricular elastance (Elv)), augmented ventricular-vascular coupling ratios (Ea/Elv) and systemic inflammation. Acute inflammation may impact ventricular-vascular coupling and predispose older adults to cardiovascular events. However, physically active older adults have more compliant large arteries and left ventricles and lower inflammation than sedentary older adults. We hypothesized that acute inflammation would alter Ea, Elv, and Ea/Elv more in older versus younger adults but that higher levels of physical activity would attenuate inflammation-induced changes. Methods: End-systolic and central blood pressures were obtained using applanation tonometry before and at 24 and 48 h post-influenza vaccination in 24 older and 38 younger adults. Ultrasonography was used to measure ventricular volumes and other indices of cardiac performance. Physical activity was measured with accelerometry. Results: Ea and Ea/Elv were maintained (p > 0.05), but Elv was reduced (p < 0.05) 24 h post-inflammation. Other indices of systolic performance were reduced in older but not younger adults; diastolic performance was attenuated in both groups 24 h post-inflammation (p < 0.05 for all). Older, but not younger, adults decreased central pressure during inflammation (p < 0.05). When controlled for age, physical activity was not related to the inflammation-induced changes in elastance (p > 0.05) except in the most active group of seniors (p < 0.05). Conclusions: Aging did not affect the elastance responses but did affect central blood pressure and other ventricular systolic responses to acute inflammation. Aging, not physical activity, appears to modulate cardiovascular responses to acute inflammation, except in the most active older adults.",
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AU - Lane, Abbi D.

AU - Kappus, Rebecca M.

AU - Bunsawat, Kanokwan

AU - Ranadive, Sushant M.

AU - Yan, Huimin

AU - Phillips, Shane

AU - Baynard, Tracy

AU - Woods, Jeffrey A.

AU - Motl, Robert

AU - Fernhall, Bo

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N2 - Background: Aging is commonly accompanied by increased arterial and ventricular stiffness (determined by arterial elastance (Ea) and ventricular elastance (Elv)), augmented ventricular-vascular coupling ratios (Ea/Elv) and systemic inflammation. Acute inflammation may impact ventricular-vascular coupling and predispose older adults to cardiovascular events. However, physically active older adults have more compliant large arteries and left ventricles and lower inflammation than sedentary older adults. We hypothesized that acute inflammation would alter Ea, Elv, and Ea/Elv more in older versus younger adults but that higher levels of physical activity would attenuate inflammation-induced changes. Methods: End-systolic and central blood pressures were obtained using applanation tonometry before and at 24 and 48 h post-influenza vaccination in 24 older and 38 younger adults. Ultrasonography was used to measure ventricular volumes and other indices of cardiac performance. Physical activity was measured with accelerometry. Results: Ea and Ea/Elv were maintained (p > 0.05), but Elv was reduced (p < 0.05) 24 h post-inflammation. Other indices of systolic performance were reduced in older but not younger adults; diastolic performance was attenuated in both groups 24 h post-inflammation (p < 0.05 for all). Older, but not younger, adults decreased central pressure during inflammation (p < 0.05). When controlled for age, physical activity was not related to the inflammation-induced changes in elastance (p > 0.05) except in the most active group of seniors (p < 0.05). Conclusions: Aging did not affect the elastance responses but did affect central blood pressure and other ventricular systolic responses to acute inflammation. Aging, not physical activity, appears to modulate cardiovascular responses to acute inflammation, except in the most active older adults.

AB - Background: Aging is commonly accompanied by increased arterial and ventricular stiffness (determined by arterial elastance (Ea) and ventricular elastance (Elv)), augmented ventricular-vascular coupling ratios (Ea/Elv) and systemic inflammation. Acute inflammation may impact ventricular-vascular coupling and predispose older adults to cardiovascular events. However, physically active older adults have more compliant large arteries and left ventricles and lower inflammation than sedentary older adults. We hypothesized that acute inflammation would alter Ea, Elv, and Ea/Elv more in older versus younger adults but that higher levels of physical activity would attenuate inflammation-induced changes. Methods: End-systolic and central blood pressures were obtained using applanation tonometry before and at 24 and 48 h post-influenza vaccination in 24 older and 38 younger adults. Ultrasonography was used to measure ventricular volumes and other indices of cardiac performance. Physical activity was measured with accelerometry. Results: Ea and Ea/Elv were maintained (p > 0.05), but Elv was reduced (p < 0.05) 24 h post-inflammation. Other indices of systolic performance were reduced in older but not younger adults; diastolic performance was attenuated in both groups 24 h post-inflammation (p < 0.05 for all). Older, but not younger, adults decreased central pressure during inflammation (p < 0.05). When controlled for age, physical activity was not related to the inflammation-induced changes in elastance (p > 0.05) except in the most active group of seniors (p < 0.05). Conclusions: Aging did not affect the elastance responses but did affect central blood pressure and other ventricular systolic responses to acute inflammation. Aging, not physical activity, appears to modulate cardiovascular responses to acute inflammation, except in the most active older adults.

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