Age-related dendritic hypertrophy and sexual dimorphism in rat basolateral amygdala

Marisa J. Rubinow; Lauren L. Drogos; Janice M. Juraska

doi:10.1016/j.neurobiolaging.2007.05.006

Age-related dendritic hypertrophy and sexual dimorphism in rat basolateral amygdala

Marisa J. Rubinow, Lauren L. Drogos, Janice M. Juraska

Research output: Contribution to journal › Article › peer-review

Abstract

Little research has examined the influence of aging or sex on anatomical measures in the basolateral amygdala. We quantified spine density and dendritic material in Golgi-Cox stained tissue of the basolateral nucleus in young adult (3-5 months) and aged (20-24 months) male and female Long-Evans rats. Dendritic branching and spine density were measured in principal neurons. Age, but not sex, influenced the dendritic tree, with aged animals displaying significantly more dendritic material. Previous findings from our laboratory in the same set of subjects indicate an opposite effect of aging on dendritic material in the medial prefrontal cortex and hippocampus. We also report here a sex difference across ages in dendritic spine density, favoring males.

Original language	English (US)
Pages (from-to)	137-146
Number of pages	10
Journal	Neurobiology of Aging
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.neurobiolaging.2007.05.006
State	Published - Jan 2009

Keywords

Aging
Basolateral nucleus
Dendrites
Dendritic spines
Golgi-Cox
Sex difference

ASJC Scopus subject areas

Neuroscience(all)
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

Online availability

10.1016/j.neurobiolaging.2007.05.006

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title = "Age-related dendritic hypertrophy and sexual dimorphism in rat basolateral amygdala",

abstract = "Little research has examined the influence of aging or sex on anatomical measures in the basolateral amygdala. We quantified spine density and dendritic material in Golgi-Cox stained tissue of the basolateral nucleus in young adult (3-5 months) and aged (20-24 months) male and female Long-Evans rats. Dendritic branching and spine density were measured in principal neurons. Age, but not sex, influenced the dendritic tree, with aged animals displaying significantly more dendritic material. Previous findings from our laboratory in the same set of subjects indicate an opposite effect of aging on dendritic material in the medial prefrontal cortex and hippocampus. We also report here a sex difference across ages in dendritic spine density, favoring males.",

keywords = "Aging, Basolateral nucleus, Dendrites, Dendritic spines, Golgi-Cox, Sex difference",

author = "Rubinow, {Marisa J.} and Drogos, {Lauren L.} and Juraska, {Janice M.}",

note = "Funding Information: The authors thank Dr. Julie Markham and Lori Scardina for their contributions to this study. This work was supported by NIH AG 18046, AG 022499 and NSF IBN 0136468. M.J.R. was supported by NIH HD07333. Portions of this study were presented at the International Behavioral Neuroscience Society and Society for Neuroscience Annual Conferences in 2005. ",

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doi = "10.1016/j.neurobiolaging.2007.05.006",

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AU - Rubinow, Marisa J.

AU - Drogos, Lauren L.

AU - Juraska, Janice M.

N1 - Funding Information: The authors thank Dr. Julie Markham and Lori Scardina for their contributions to this study. This work was supported by NIH AG 18046, AG 022499 and NSF IBN 0136468. M.J.R. was supported by NIH HD07333. Portions of this study were presented at the International Behavioral Neuroscience Society and Society for Neuroscience Annual Conferences in 2005.

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N2 - Little research has examined the influence of aging or sex on anatomical measures in the basolateral amygdala. We quantified spine density and dendritic material in Golgi-Cox stained tissue of the basolateral nucleus in young adult (3-5 months) and aged (20-24 months) male and female Long-Evans rats. Dendritic branching and spine density were measured in principal neurons. Age, but not sex, influenced the dendritic tree, with aged animals displaying significantly more dendritic material. Previous findings from our laboratory in the same set of subjects indicate an opposite effect of aging on dendritic material in the medial prefrontal cortex and hippocampus. We also report here a sex difference across ages in dendritic spine density, favoring males.

AB - Little research has examined the influence of aging or sex on anatomical measures in the basolateral amygdala. We quantified spine density and dendritic material in Golgi-Cox stained tissue of the basolateral nucleus in young adult (3-5 months) and aged (20-24 months) male and female Long-Evans rats. Dendritic branching and spine density were measured in principal neurons. Age, but not sex, influenced the dendritic tree, with aged animals displaying significantly more dendritic material. Previous findings from our laboratory in the same set of subjects indicate an opposite effect of aging on dendritic material in the medial prefrontal cortex and hippocampus. We also report here a sex difference across ages in dendritic spine density, favoring males.

KW - Aging

KW - Basolateral nucleus

KW - Dendrites

KW - Dendritic spines

KW - Golgi-Cox

KW - Sex difference

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Age-related dendritic hypertrophy and sexual dimorphism in rat basolateral amygdala

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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