Age-related dendritic hypertrophy and sexual dimorphism in rat basolateral amygdala

Marisa J. Rubinow, Lauren L. Drogos, Janice M. Juraska

Research output: Contribution to journalArticlepeer-review

Abstract

Little research has examined the influence of aging or sex on anatomical measures in the basolateral amygdala. We quantified spine density and dendritic material in Golgi-Cox stained tissue of the basolateral nucleus in young adult (3-5 months) and aged (20-24 months) male and female Long-Evans rats. Dendritic branching and spine density were measured in principal neurons. Age, but not sex, influenced the dendritic tree, with aged animals displaying significantly more dendritic material. Previous findings from our laboratory in the same set of subjects indicate an opposite effect of aging on dendritic material in the medial prefrontal cortex and hippocampus. We also report here a sex difference across ages in dendritic spine density, favoring males.

Original languageEnglish (US)
Pages (from-to)137-146
Number of pages10
JournalNeurobiology of Aging
Volume30
Issue number1
DOIs
StatePublished - Jan 2009

Keywords

  • Aging
  • Basolateral nucleus
  • Dendrites
  • Dendritic spines
  • Golgi-Cox
  • Sex difference

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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