Age-associated alterations in catecholaminergic concentrations, neuronal activity, and α1 receptor densities in female rats

Nancy G. Weiland; Ilene R. Cohen; Phyllis M. Wise

doi:10.1016/0197-4580(89)90043-2

Age-associated alterations in catecholaminergic concentrations, neuronal activity, and α₁ receptor densities in female rats

Nancy G. Weiland, Ilene R. Cohen, Phyllis M. Wise

Research output: Contribution to journal › Article › peer-review

Abstract

The density of α₁-adrenergic receptors and catecholamine concentrations and neuronal activity were assessed in selected estrogen-responsive regions of the hypothalamus and pineal glands. The results of this study demonstrate that the densities of α₁-adrenergic receptors and norepinephrine and epinephrine concentrations and activity rate constants are altered in aged rats. The direction and extent of the change depend on the specific brain region and reproductive state of the animals. No widespread decline with increased age was observed in any of the parameters measured.

Original language	English (US)
Pages (from-to)	323-329
Number of pages	7
Journal	Neurobiology of Aging
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/0197-4580(89)90043-2
State	Published - 1989
Externally published	Yes

Keywords

Aging
Constant estrus
Epinephrine
Norepinephrine
Persistently pseudopregnant
α-adrenergic receptors

ASJC Scopus subject areas

General Neuroscience
Aging
Developmental Biology
Clinical Neurology
Geriatrics and Gerontology

Online availability

10.1016/0197-4580(89)90043-2

Library availability

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Cite this

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title = "Age-associated alterations in catecholaminergic concentrations, neuronal activity, and α1 receptor densities in female rats",

abstract = "The density of α1-adrenergic receptors and catecholamine concentrations and neuronal activity were assessed in selected estrogen-responsive regions of the hypothalamus and pineal glands. The results of this study demonstrate that the densities of α1-adrenergic receptors and norepinephrine and epinephrine concentrations and activity rate constants are altered in aged rats. The direction and extent of the change depend on the specific brain region and reproductive state of the animals. No widespread decline with increased age was observed in any of the parameters measured.",

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AU - Weiland, Nancy G.

AU - Cohen, Ilene R.

AU - Wise, Phyllis M.

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Y1 - 1989

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AB - The density of α1-adrenergic receptors and catecholamine concentrations and neuronal activity were assessed in selected estrogen-responsive regions of the hypothalamus and pineal glands. The results of this study demonstrate that the densities of α1-adrenergic receptors and norepinephrine and epinephrine concentrations and activity rate constants are altered in aged rats. The direction and extent of the change depend on the specific brain region and reproductive state of the animals. No widespread decline with increased age was observed in any of the parameters measured.

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KW - Constant estrus

KW - Epinephrine

KW - Norepinephrine

KW - Persistently pseudopregnant

KW - α-adrenergic receptors

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