Age-associated alterations in catecholaminergic concentrations, neuronal activity, and α1 receptor densities in female rats

Nancy G. Weiland, Ilene R. Cohen, Phyllis M. Wise

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The density of α1-adrenergic receptors and catecholamine concentrations and neuronal activity were assessed in selected estrogen-responsive regions of the hypothalamus and pineal glands. The results of this study demonstrate that the densities of α1-adrenergic receptors and norepinephrine and epinephrine concentrations and activity rate constants are altered in aged rats. The direction and extent of the change depend on the specific brain region and reproductive state of the animals. No widespread decline with increased age was observed in any of the parameters measured.

    Original languageEnglish (US)
    Pages (from-to)323-329
    Number of pages7
    JournalNeurobiology of Aging
    Volume10
    Issue number4
    DOIs
    StatePublished - 1989

    Keywords

    • Aging
    • Constant estrus
    • Epinephrine
    • Norepinephrine
    • Persistently pseudopregnant
    • α-adrenergic receptors

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Aging
    • Clinical Neurology
    • Developmental Biology
    • Geriatrics and Gerontology

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