Age and sex differences in behavioral flexibility, sensitivity to reward value, and risky decision-making

Sara R. Westbrook, Emily R. Hankosky, Megan R. Dwyer, Joshua M Gulley

Research output: Contribution to journalArticle

Abstract

Compared with adults, adolescent behavior is often characterized by reduced behavioral flexibility, increased sensitivity to reward, and increased likelihood to take risks. These traits, which have been hypothesized to confer heightened vulnerability to psychopathologies such as substance use disorders (SUDs), have been the focus of studies in laboratory animal models that seek to understand their neural underpinnings. However, rodent studies to date have typically used only males and have adopted standard methodological practices (e.g., weight loss inducing food restriction) that are likely to have a disparate impact on adolescents compared with adults. Here, we used adolescent and adult Sprague-Dawley rats of both sexes to study instrumental behavior tasks that assess behavioral flexibility (strategy shifting and reversal learning; Experiment 1), sensitivity to reward value (outcome devaluation; Experiment 2), and risky decision making (probability discounting; Experiment 3). In Experiment 1, we found that adolescents were faster to acquire reversal learning than adults but there were no differences in strategy shifting. In Experiments 2 and 3, adolescents and adults were equally sensitive to changes in reward value and exhibited similar reductions in preference for a large reward when reinforcement probability was decreased. However, adolescents responded more efficiently and earned reinforcers at a higher rate than their same-sex, adult counterparts. Together, these findings provide only limited support for the existence of an "adolescent-typical" phenotype in Sprague-Dawley rats and instead suggest that age differences in the expression of these behaviors may depend on conditions such as pubertal status and motivational state.

Original languageEnglish (US)
Pages (from-to)75-87
Number of pages13
JournalBehavioral Neuroscience
Volume132
Issue number2
DOIs
StatePublished - Apr 1 2018

Fingerprint

Reward
Sex Characteristics
Decision Making
Reversal Learning
Sprague Dawley Rats
Adolescent Behavior
Psychopathology
Substance-Related Disorders
Weight Loss
Rodentia
Animal Models
Phenotype
Food

Keywords

  • Adolescence
  • Behavioral flexibility
  • Reward sensitivity
  • Risk-taking

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Age and sex differences in behavioral flexibility, sensitivity to reward value, and risky decision-making. / Westbrook, Sara R.; Hankosky, Emily R.; Dwyer, Megan R.; Gulley, Joshua M.

In: Behavioral Neuroscience, Vol. 132, No. 2, 01.04.2018, p. 75-87.

Research output: Contribution to journalArticle

Westbrook, Sara R. ; Hankosky, Emily R. ; Dwyer, Megan R. ; Gulley, Joshua M. / Age and sex differences in behavioral flexibility, sensitivity to reward value, and risky decision-making. In: Behavioral Neuroscience. 2018 ; Vol. 132, No. 2. pp. 75-87.
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