Age alters dopaminergic responses to estradiol

Edward J. Roy; Susan Sheinkop; Marlene A. Wilson

doi:10.1016/0014-2999(82)90554-4

Age alters dopaminergic responses to estradiol

Edward J. Roy, Susan Sheinkop, Marlene A. Wilson

Research output: Contribution to journal › Article › peer-review

Abstract

Young (3-5 months) and middle-aged (17-19 months) ovariectomized rats were treated with estradiol benzoate for three days and striatal dopaminergic function was assessed behaviorally (circling in response to apomorphine) and neurochemically (binding of [³H]spiroperiodoly striatal membranes). The results suggest that striatal dopaminergic function may respond differently to estrogen in older animals compared to younger animals.

Original language	English (US)
Pages (from-to)	73-75
Number of pages	3
Journal	European Journal of Pharmacology
Volume	82
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-2999(82)90554-4
State	Published - Aug 13 1982

Keywords

Age
Dopamine
Estrogens

ASJC Scopus subject areas

Pharmacology

Online availability

10.1016/0014-2999(82)90554-4

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title = "Age alters dopaminergic responses to estradiol",

abstract = "Young (3-5 months) and middle-aged (17-19 months) ovariectomized rats were treated with estradiol benzoate for three days and striatal dopaminergic function was assessed behaviorally (circling in response to apomorphine) and neurochemically (binding of [3H]spiroperiodoly striatal membranes). The results suggest that striatal dopaminergic function may respond differently to estrogen in older animals compared to younger animals.",

keywords = "Age, Dopamine, Estrogens",

author = "Roy, {Edward J.} and Susan Sheinkop and Wilson, {Marlene A.}",

note = "Funding Information: We would like to thank Aretta Weber for assistance in preparation of the manuscript and graphics, and Esther Williams for assistance in adapting the Ligand program of Munson and Rodbard. Supported by NIMH MH 33577 to EJR.",

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doi = "10.1016/0014-2999(82)90554-4",

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AU - Sheinkop, Susan

AU - Wilson, Marlene A.

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PY - 1982/8/13

Y1 - 1982/8/13

N2 - Young (3-5 months) and middle-aged (17-19 months) ovariectomized rats were treated with estradiol benzoate for three days and striatal dopaminergic function was assessed behaviorally (circling in response to apomorphine) and neurochemically (binding of [3H]spiroperiodoly striatal membranes). The results suggest that striatal dopaminergic function may respond differently to estrogen in older animals compared to younger animals.

AB - Young (3-5 months) and middle-aged (17-19 months) ovariectomized rats were treated with estradiol benzoate for three days and striatal dopaminergic function was assessed behaviorally (circling in response to apomorphine) and neurochemically (binding of [3H]spiroperiodoly striatal membranes). The results suggest that striatal dopaminergic function may respond differently to estrogen in older animals compared to younger animals.

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KW - Dopamine

KW - Estrogens

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Age alters dopaminergic responses to estradiol

Abstract

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