TY - CHAP
T1 - African swine fever virus
AU - Tulman, E. R.
AU - Delhon, G. A.
AU - Ku, B. K.
AU - Rock, D. L.
PY - 2009
Y1 - 2009
N2 - African swine fever virus (ASFV) is a large, intracytoplasmically- replicating DNA arbovirus and the sole member of the family Asfarviridae. It is the etiologic agent of a highly lethal hemorrhagic disease of domestic swine and therefore extensively studied to elucidate the structures, genes, and mechanisms affecting viral replication in the host, virus-host interactions, and viral virulence. Increasingly apparent is the complexity with which ASFV replicates and interacts with the host cell during infection. ASFV encodes novel genes involved in host immune response modulation, viral virulence for domestic swine, and in the ability of ASFV to replicate and spread in its tick vector. The unique nature of ASFV has contributed to a broader understanding of DNA virus/host interactions.
AB - African swine fever virus (ASFV) is a large, intracytoplasmically- replicating DNA arbovirus and the sole member of the family Asfarviridae. It is the etiologic agent of a highly lethal hemorrhagic disease of domestic swine and therefore extensively studied to elucidate the structures, genes, and mechanisms affecting viral replication in the host, virus-host interactions, and viral virulence. Increasingly apparent is the complexity with which ASFV replicates and interacts with the host cell during infection. ASFV encodes novel genes involved in host immune response modulation, viral virulence for domestic swine, and in the ability of ASFV to replicate and spread in its tick vector. The unique nature of ASFV has contributed to a broader understanding of DNA virus/host interactions.
UR - http://www.scopus.com/inward/record.url?scp=58249121016&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58249121016&partnerID=8YFLogxK
U2 - 10.1007/978-3-540-68618-7_2
DO - 10.1007/978-3-540-68618-7_2
M3 - Chapter
C2 - 19216435
AN - SCOPUS:58249121016
SN - 9783540686170
T3 - Current Topics in Microbiology and Immunology
SP - 43
EP - 87
BT - Lesser Known Large dsDNA Viruses
PB - Springer
ER -