Aerobic fitness is associated with greater white matter integrity in children

Laura Chaddock-Heyman, Kirk I. Erickson, Joseph L. Holtrop, Michelle W. Voss, Matthew B. Pontifex, Lauren B. Raine, Charles H. Hillman, Arthur F. Kramer

Research output: Contribution to journalArticle

Abstract

Aerobic fitness has been found to play a positive role in brain and cognitive health of children. Yet, many of the neural biomarkers related to aerobic fitness remain unknown. Here, using diffusion tensor imaging, we demonstrated that higher aerobic fitness was related to greater estimates of white matter microstructure in children. Higher fit 9- and 10-year-old children showed greater fractional anisotropy (FA) in sections of the corpus callosum, corona radiata, and superior longitudinal fasciculus, compared to lower fit children. The FA effects were primarily characterized by aerobic fitness differences in radial diffusivity, thereby raising the possibility that estimates of myelination may vary as a function of individual differences in fitness during childhood. White matter structure may be another potential neural mechanism of aerobic fitness that assists in efficient communication between gray matter regions as well as the integration of regions into networks.

Original languageEnglish (US)
Article number584
JournalFrontiers in Human Neuroscience
Volume8
Issue numberAUG
DOIs
StatePublished - Aug 19 2014

Fingerprint

Anisotropy
Diffusion Tensor Imaging
Corpus Callosum
Individuality
Biomarkers
Communication
Brain
White Matter
Child Health
Gray Matter

Keywords

  • Cardiorespiratory fitness
  • Development
  • Diffusion tensor imaging
  • Fiber tracts
  • Microstructure

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Chaddock-Heyman, L., Erickson, K. I., Holtrop, J. L., Voss, M. W., Pontifex, M. B., Raine, L. B., ... Kramer, A. F. (2014). Aerobic fitness is associated with greater white matter integrity in children. Frontiers in Human Neuroscience, 8(AUG), [584]. https://doi.org/10.3389/fnhum.2014.00584

Aerobic fitness is associated with greater white matter integrity in children. / Chaddock-Heyman, Laura; Erickson, Kirk I.; Holtrop, Joseph L.; Voss, Michelle W.; Pontifex, Matthew B.; Raine, Lauren B.; Hillman, Charles H.; Kramer, Arthur F.

In: Frontiers in Human Neuroscience, Vol. 8, No. AUG, 584, 19.08.2014.

Research output: Contribution to journalArticle

Chaddock-Heyman, L, Erickson, KI, Holtrop, JL, Voss, MW, Pontifex, MB, Raine, LB, Hillman, CH & Kramer, AF 2014, 'Aerobic fitness is associated with greater white matter integrity in children', Frontiers in Human Neuroscience, vol. 8, no. AUG, 584. https://doi.org/10.3389/fnhum.2014.00584
Chaddock-Heyman L, Erickson KI, Holtrop JL, Voss MW, Pontifex MB, Raine LB et al. Aerobic fitness is associated with greater white matter integrity in children. Frontiers in Human Neuroscience. 2014 Aug 19;8(AUG). 584. https://doi.org/10.3389/fnhum.2014.00584
Chaddock-Heyman, Laura ; Erickson, Kirk I. ; Holtrop, Joseph L. ; Voss, Michelle W. ; Pontifex, Matthew B. ; Raine, Lauren B. ; Hillman, Charles H. ; Kramer, Arthur F. / Aerobic fitness is associated with greater white matter integrity in children. In: Frontiers in Human Neuroscience. 2014 ; Vol. 8, No. AUG.
@article{f084aa8f50764d3590b5db36ea4a53ff,
title = "Aerobic fitness is associated with greater white matter integrity in children",
abstract = "Aerobic fitness has been found to play a positive role in brain and cognitive health of children. Yet, many of the neural biomarkers related to aerobic fitness remain unknown. Here, using diffusion tensor imaging, we demonstrated that higher aerobic fitness was related to greater estimates of white matter microstructure in children. Higher fit 9- and 10-year-old children showed greater fractional anisotropy (FA) in sections of the corpus callosum, corona radiata, and superior longitudinal fasciculus, compared to lower fit children. The FA effects were primarily characterized by aerobic fitness differences in radial diffusivity, thereby raising the possibility that estimates of myelination may vary as a function of individual differences in fitness during childhood. White matter structure may be another potential neural mechanism of aerobic fitness that assists in efficient communication between gray matter regions as well as the integration of regions into networks.",
keywords = "Cardiorespiratory fitness, Development, Diffusion tensor imaging, Fiber tracts, Microstructure",
author = "Laura Chaddock-Heyman and Erickson, {Kirk I.} and Holtrop, {Joseph L.} and Voss, {Michelle W.} and Pontifex, {Matthew B.} and Raine, {Lauren B.} and Hillman, {Charles H.} and Kramer, {Arthur F.}",
year = "2014",
month = "8",
day = "19",
doi = "10.3389/fnhum.2014.00584",
language = "English (US)",
volume = "8",
journal = "Frontiers in Human Neuroscience",
issn = "1662-5161",
publisher = "Frontiers Research Foundation",
number = "AUG",

}

TY - JOUR

T1 - Aerobic fitness is associated with greater white matter integrity in children

AU - Chaddock-Heyman, Laura

AU - Erickson, Kirk I.

AU - Holtrop, Joseph L.

AU - Voss, Michelle W.

AU - Pontifex, Matthew B.

AU - Raine, Lauren B.

AU - Hillman, Charles H.

AU - Kramer, Arthur F.

PY - 2014/8/19

Y1 - 2014/8/19

N2 - Aerobic fitness has been found to play a positive role in brain and cognitive health of children. Yet, many of the neural biomarkers related to aerobic fitness remain unknown. Here, using diffusion tensor imaging, we demonstrated that higher aerobic fitness was related to greater estimates of white matter microstructure in children. Higher fit 9- and 10-year-old children showed greater fractional anisotropy (FA) in sections of the corpus callosum, corona radiata, and superior longitudinal fasciculus, compared to lower fit children. The FA effects were primarily characterized by aerobic fitness differences in radial diffusivity, thereby raising the possibility that estimates of myelination may vary as a function of individual differences in fitness during childhood. White matter structure may be another potential neural mechanism of aerobic fitness that assists in efficient communication between gray matter regions as well as the integration of regions into networks.

AB - Aerobic fitness has been found to play a positive role in brain and cognitive health of children. Yet, many of the neural biomarkers related to aerobic fitness remain unknown. Here, using diffusion tensor imaging, we demonstrated that higher aerobic fitness was related to greater estimates of white matter microstructure in children. Higher fit 9- and 10-year-old children showed greater fractional anisotropy (FA) in sections of the corpus callosum, corona radiata, and superior longitudinal fasciculus, compared to lower fit children. The FA effects were primarily characterized by aerobic fitness differences in radial diffusivity, thereby raising the possibility that estimates of myelination may vary as a function of individual differences in fitness during childhood. White matter structure may be another potential neural mechanism of aerobic fitness that assists in efficient communication between gray matter regions as well as the integration of regions into networks.

KW - Cardiorespiratory fitness

KW - Development

KW - Diffusion tensor imaging

KW - Fiber tracts

KW - Microstructure

UR - http://www.scopus.com/inward/record.url?scp=84932108276&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84932108276&partnerID=8YFLogxK

U2 - 10.3389/fnhum.2014.00584

DO - 10.3389/fnhum.2014.00584

M3 - Article

AN - SCOPUS:84932108276

VL - 8

JO - Frontiers in Human Neuroscience

JF - Frontiers in Human Neuroscience

SN - 1662-5161

IS - AUG

M1 - 584

ER -