Aerobic fitness is associated with greater hippocampal cerebral blood flow in children

Laura Chaddock-Heyman, Kirk I. Erickson, Michael A. Chappell, Curtis L. Johnson, Caitlin Kienzler, Anya Knecht, Eric S. Drollette, Lauren B. Raine, Mark R. Scudder, Shih Chun Kao, Charles H. Hillman, Arthur F. Kramer

Research output: Contribution to journalArticle

Abstract

The present study is the first to investigate whether cerebral blood flow in the hippocampus relates to aerobic fitness in children. In particular, we used arterial spin labeling (ASL) perfusion MRI to provide a quantitative measure of blood flow in the hippocampus in 73 7- to 9-year-old preadolescent children. Indeed, aerobic fitness was found to relate to greater perfusion in the hippocampus, independent of age, sex, and hippocampal volume. Such results suggest improved microcirculation and cerebral vasculature in preadolescent children with higher levels of aerobic fitness. Further, aerobic fitness may influence how the brain regulates its metabolic demands via blood flow in a region of the brain important for learning and memory. To add specificity to the relationship of fitness to the hippocampus, we demonstrate no significant association between aerobic fitness and cerebral blood flow in the brainstem. Our results reinforce the importance of aerobic fitness during a critical period of child development.

Original languageEnglish (US)
Pages (from-to)52-58
Number of pages7
JournalDevelopmental Cognitive Neuroscience
Volume20
DOIs
StatePublished - Aug 1 2016

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Cerebrovascular Circulation
Hippocampus
Perfusion
Brain
Microcirculation
Child Development
Brain Stem
Learning

Keywords

  • Arterial spin labeling
  • Childhood
  • Development
  • Hippocampus
  • Perfusion
  • Physical activity

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Chaddock-Heyman, L., Erickson, K. I., Chappell, M. A., Johnson, C. L., Kienzler, C., Knecht, A., ... Kramer, A. F. (2016). Aerobic fitness is associated with greater hippocampal cerebral blood flow in children. Developmental Cognitive Neuroscience, 20, 52-58. https://doi.org/10.1016/j.dcn.2016.07.001

Aerobic fitness is associated with greater hippocampal cerebral blood flow in children. / Chaddock-Heyman, Laura; Erickson, Kirk I.; Chappell, Michael A.; Johnson, Curtis L.; Kienzler, Caitlin; Knecht, Anya; Drollette, Eric S.; Raine, Lauren B.; Scudder, Mark R.; Kao, Shih Chun; Hillman, Charles H.; Kramer, Arthur F.

In: Developmental Cognitive Neuroscience, Vol. 20, 01.08.2016, p. 52-58.

Research output: Contribution to journalArticle

Chaddock-Heyman, L, Erickson, KI, Chappell, MA, Johnson, CL, Kienzler, C, Knecht, A, Drollette, ES, Raine, LB, Scudder, MR, Kao, SC, Hillman, CH & Kramer, AF 2016, 'Aerobic fitness is associated with greater hippocampal cerebral blood flow in children', Developmental Cognitive Neuroscience, vol. 20, pp. 52-58. https://doi.org/10.1016/j.dcn.2016.07.001
Chaddock-Heyman L, Erickson KI, Chappell MA, Johnson CL, Kienzler C, Knecht A et al. Aerobic fitness is associated with greater hippocampal cerebral blood flow in children. Developmental Cognitive Neuroscience. 2016 Aug 1;20:52-58. https://doi.org/10.1016/j.dcn.2016.07.001
Chaddock-Heyman, Laura ; Erickson, Kirk I. ; Chappell, Michael A. ; Johnson, Curtis L. ; Kienzler, Caitlin ; Knecht, Anya ; Drollette, Eric S. ; Raine, Lauren B. ; Scudder, Mark R. ; Kao, Shih Chun ; Hillman, Charles H. ; Kramer, Arthur F. / Aerobic fitness is associated with greater hippocampal cerebral blood flow in children. In: Developmental Cognitive Neuroscience. 2016 ; Vol. 20. pp. 52-58.
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