Although biotin and lipoic acid are two universally conserved cofactors essential for intermediary metabolism, their synthetic pathways have become known only in recent years. Both pathways have unusual features. Biotin synthesis in Escherichia coli requires a methylation that is later removed whereas lipoic acid is assembled on the enzymes where it is required for activity by two different pathways.
|Original language||English (US)|
|Number of pages||7|
|Journal||Current Opinion in Chemical Biology|
|State||Published - Dec 2018|
ASJC Scopus subject areas
- Analytical Chemistry