Advances in synthesis of biotin and assembly of lipoic acid

Research output: Contribution to journalReview article

Abstract

Although biotin and lipoic acid are two universally conserved cofactors essential for intermediary metabolism, their synthetic pathways have become known only in recent years. Both pathways have unusual features. Biotin synthesis in Escherichia coli requires a methylation that is later removed whereas lipoic acid is assembled on the enzymes where it is required for activity by two different pathways.

Original languageEnglish (US)
Pages (from-to)60-66
Number of pages7
JournalCurrent Opinion in Chemical Biology
Volume47
DOIs
StatePublished - Dec 2018

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Thioctic Acid
Biotin
Methylation
Metabolism
Escherichia coli
Enzymes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

Cite this

Advances in synthesis of biotin and assembly of lipoic acid. / Cronan, John E.

In: Current Opinion in Chemical Biology, Vol. 47, 12.2018, p. 60-66.

Research output: Contribution to journalReview article

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