Advances in exercise therapy in predialysis chronic kidney disease, hemodialysis, peritoneal dialysis, and kidney transplantation

Global Renal Exercise Network

Research output: Contribution to journalReview articlepeer-review


Purpose of reviewChronic kidney disease (CKD) is characterized by poor levels of physical activity which contribute to increased morbidity across the disease trajectory. The short nature, small samples, and poor methodology across most studies have failed to translate the role of exercise in CKD into its adoption as a frontline adjunct therapeutic option. This review focuses on recent advances surrounding the benefits of exercise interventions across the CKD spectrum.Recent findingsKey recent advances in exercise studies have focused on the efficacy of novel intervention strategies across the CKD spectrum. These include high-intensity interval training, virtual reality gaming, intradialytic yoga, electrical stimulation of muscles, blood flow restriction training, and protocols combining exercise with nutritional supplementation. Research is also beginning to explore the role of prehabilitation for patients prior to dialysis and kidney transplantation.SummaryStudies continue to demonstrate wide-ranging benefits of exercise across CKD; however, implementation of exercise remains scarce. Future research needs include evaluating the efficacy of larger and/or more comprehensive interventions on clinically important outcomes. It is hoped with increasing global evidence, high-quality clinical studies, and sustained clinician and patient engagement, exercise programs will become better prioritized in the nephrology field.

Original languageEnglish (US)
Pages (from-to)471-479
Number of pages9
JournalCurrent Opinion in Nephrology and Hypertension
Issue number5
StatePublished - Sep 1 2020


  • chronic kidney disease
  • dialysis
  • exercise
  • intradialytic exercise
  • physical activity
  • physical function

ASJC Scopus subject areas

  • Nephrology
  • Internal Medicine


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