Advanced laser system for 3D optoacoustic tomography of the breast

Marc Klosner, Gary Chan, Chunbai Wu, Donald F. Heller, Richard Su, Sergey Ermilov, Hans Peter Brecht, Vassili Ivanov, Pratik Talole, Yang Lou, Mark Anastasio, Alexander Oraevsky

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We describe the ongoing development and performance of a high-pulse-energy wavelength-cycling laser system for three-dimensional optoacoustic tomography of the breast. Joule-level energies are desired for achieving the required penetration depths while maintaining safe fluence levels. Wavelength cycling provides a pulse sequence which repeatedly alternates between two wavelengths (approximately 756 and 797 nm) that provide differential imaging. This improves co-registration of captured differential images and quantification of blood oxygen saturation. New design features have been developed for and incorporated into a clinical prototype laser system, to improve efficacy and ease of use in the clinic. We describe the benefits of these features for operation with a clinical pilot optoacoustic/ultrasound dual-modality three-dimensional imaging system.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2016
EditorsAlexander A. Oraevsky, Lihong V. Wang
ISBN (Electronic)9781628419429
StatePublished - 2016
Externally publishedYes
EventPhotons Plus Ultrasound: Imaging and Sensing 2016 - San Francisco, United States
Duration: Feb 14 2016Feb 17 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferencePhotons Plus Ultrasound: Imaging and Sensing 2016
Country/TerritoryUnited States
CitySan Francisco


  • alexandrite laser
  • breast cancer
  • mammography
  • Optoacoustic imaging
  • photoacoustic imaging
  • pulsed laser
  • tomography
  • tumor

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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