TY - JOUR
T1 - Adolescent depression linked to socioeconomic status? Molecular approaches for revealing premorbid risk factors
AU - Uddin, Monica
AU - Jansen, Stefan
AU - Telzer, Eva H.
N1 - Publisher Copyright:
© 2017 WILEY Periodicals, Inc.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - The means by which social environmental exposures influence risk of mental disorders is a persistent and still open question. A key candidate mechanism for the biologic mediation of environmental effects involves epigenetic factors, which regulate gene function without altering underlying DNA sequence. Recent work has shown that environmental exposures such as childhood abuse, family history of mental disorder, and low socioeconomic status (SES) associate with differential DNA methylation (5mC) – a relatively stable, but modifiable, epigenetic factor. However, the longitudinal relation among SES, 5mC, brain function, and risk of depression remains to be elucidated. Here, we briefly review literature relevant to these associations and discuss recent findings that, for the first time, prospectively demonstrate sequential links between low SES, changes in 5mC, changes in brain function, and risk of depression in a cohort of adolescents.
AB - The means by which social environmental exposures influence risk of mental disorders is a persistent and still open question. A key candidate mechanism for the biologic mediation of environmental effects involves epigenetic factors, which regulate gene function without altering underlying DNA sequence. Recent work has shown that environmental exposures such as childhood abuse, family history of mental disorder, and low socioeconomic status (SES) associate with differential DNA methylation (5mC) – a relatively stable, but modifiable, epigenetic factor. However, the longitudinal relation among SES, 5mC, brain function, and risk of depression remains to be elucidated. Here, we briefly review literature relevant to these associations and discuss recent findings that, for the first time, prospectively demonstrate sequential links between low SES, changes in 5mC, changes in brain function, and risk of depression in a cohort of adolescents.
KW - biomarker
KW - epigenetics
KW - longitudinal study
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U2 - 10.1002/bies.201600194
DO - 10.1002/bies.201600194
M3 - Article
C2 - 28090662
AN - SCOPUS:85009488869
SN - 0265-9247
VL - 39
JO - BioEssays
JF - BioEssays
IS - 3
M1 - 1600194
ER -