Adolescence and reward: Making sense of neural and behavioral changes amid the chaos

Deena M. Walker, Margaret R. Bell, Cecilia Flores, Joshua M. Gulley, Jari Willing, Matthew J. Paul

Research output: Contribution to journalReview article

Abstract

Adolescence is a time of significant neural and behavioral change with remarkable development in social, emotional, and cognitive skills. It is also a time of increased exploration and risk-taking (e.g., drug use). Many of these changes are thought to be the result of increased reward-value coupled with an underdeveloped inhibitory control, and thus a hypersensitivity to reward. Perturbations during adolescence can alter the developmental trajectory of the brain, resulting in long-term alterations in reward-associated behaviors. This review highlights recent developments in our understanding of how neural circuits, pubertal hormones, and environmental factors contribute to adolescent-typical reward-associated behaviors with a particular focus on sex differences, the medial prefrontal cortex, social reward, social isolation, and drug use. We then introduce a new approach that makes use of natural adaptations of seasonally breeding species to investigate the role of pubertal hormones in adolescent development. This research has only begun to parse out contributions of the many neural, endocrine, and environmental changes to the heightened reward sensitivity and increased vulnerability to mental health disorders that characterize this life stage.

Original languageEnglish (US)
Pages (from-to)10855-10866
Number of pages12
JournalJournal of Neuroscience
Volume37
Issue number45
DOIs
StatePublished - Nov 8 2017

Fingerprint

Reward
Hormones
Adolescent Development
Social Isolation
Risk-Taking
Prefrontal Cortex
Mental Disorders
Sex Characteristics
Pharmaceutical Preparations
Breeding
Mental Health
Hypersensitivity
Brain
Research

Keywords

  • Drugs of abuse
  • Medial prefrontal cortex
  • Mesocorticolimbic dopamine pathway
  • Puberty
  • Sex differences
  • Social reward

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Adolescence and reward : Making sense of neural and behavioral changes amid the chaos. / Walker, Deena M.; Bell, Margaret R.; Flores, Cecilia; Gulley, Joshua M.; Willing, Jari; Paul, Matthew J.

In: Journal of Neuroscience, Vol. 37, No. 45, 08.11.2017, p. 10855-10866.

Research output: Contribution to journalReview article

Walker, Deena M. ; Bell, Margaret R. ; Flores, Cecilia ; Gulley, Joshua M. ; Willing, Jari ; Paul, Matthew J. / Adolescence and reward : Making sense of neural and behavioral changes amid the chaos. In: Journal of Neuroscience. 2017 ; Vol. 37, No. 45. pp. 10855-10866.
@article{ef6b1b886e694be49dab7a47961c413e,
title = "Adolescence and reward: Making sense of neural and behavioral changes amid the chaos",
abstract = "Adolescence is a time of significant neural and behavioral change with remarkable development in social, emotional, and cognitive skills. It is also a time of increased exploration and risk-taking (e.g., drug use). Many of these changes are thought to be the result of increased reward-value coupled with an underdeveloped inhibitory control, and thus a hypersensitivity to reward. Perturbations during adolescence can alter the developmental trajectory of the brain, resulting in long-term alterations in reward-associated behaviors. This review highlights recent developments in our understanding of how neural circuits, pubertal hormones, and environmental factors contribute to adolescent-typical reward-associated behaviors with a particular focus on sex differences, the medial prefrontal cortex, social reward, social isolation, and drug use. We then introduce a new approach that makes use of natural adaptations of seasonally breeding species to investigate the role of pubertal hormones in adolescent development. This research has only begun to parse out contributions of the many neural, endocrine, and environmental changes to the heightened reward sensitivity and increased vulnerability to mental health disorders that characterize this life stage.",
keywords = "Drugs of abuse, Medial prefrontal cortex, Mesocorticolimbic dopamine pathway, Puberty, Sex differences, Social reward",
author = "Walker, {Deena M.} and Bell, {Margaret R.} and Cecilia Flores and Gulley, {Joshua M.} and Jari Willing and Paul, {Matthew J.}",
year = "2017",
month = "11",
day = "8",
doi = "10.1523/JNEUROSCI.1834-17.2017",
language = "English (US)",
volume = "37",
pages = "10855--10866",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "45",

}

TY - JOUR

T1 - Adolescence and reward

T2 - Making sense of neural and behavioral changes amid the chaos

AU - Walker, Deena M.

AU - Bell, Margaret R.

AU - Flores, Cecilia

AU - Gulley, Joshua M.

AU - Willing, Jari

AU - Paul, Matthew J.

PY - 2017/11/8

Y1 - 2017/11/8

N2 - Adolescence is a time of significant neural and behavioral change with remarkable development in social, emotional, and cognitive skills. It is also a time of increased exploration and risk-taking (e.g., drug use). Many of these changes are thought to be the result of increased reward-value coupled with an underdeveloped inhibitory control, and thus a hypersensitivity to reward. Perturbations during adolescence can alter the developmental trajectory of the brain, resulting in long-term alterations in reward-associated behaviors. This review highlights recent developments in our understanding of how neural circuits, pubertal hormones, and environmental factors contribute to adolescent-typical reward-associated behaviors with a particular focus on sex differences, the medial prefrontal cortex, social reward, social isolation, and drug use. We then introduce a new approach that makes use of natural adaptations of seasonally breeding species to investigate the role of pubertal hormones in adolescent development. This research has only begun to parse out contributions of the many neural, endocrine, and environmental changes to the heightened reward sensitivity and increased vulnerability to mental health disorders that characterize this life stage.

AB - Adolescence is a time of significant neural and behavioral change with remarkable development in social, emotional, and cognitive skills. It is also a time of increased exploration and risk-taking (e.g., drug use). Many of these changes are thought to be the result of increased reward-value coupled with an underdeveloped inhibitory control, and thus a hypersensitivity to reward. Perturbations during adolescence can alter the developmental trajectory of the brain, resulting in long-term alterations in reward-associated behaviors. This review highlights recent developments in our understanding of how neural circuits, pubertal hormones, and environmental factors contribute to adolescent-typical reward-associated behaviors with a particular focus on sex differences, the medial prefrontal cortex, social reward, social isolation, and drug use. We then introduce a new approach that makes use of natural adaptations of seasonally breeding species to investigate the role of pubertal hormones in adolescent development. This research has only begun to parse out contributions of the many neural, endocrine, and environmental changes to the heightened reward sensitivity and increased vulnerability to mental health disorders that characterize this life stage.

KW - Drugs of abuse

KW - Medial prefrontal cortex

KW - Mesocorticolimbic dopamine pathway

KW - Puberty

KW - Sex differences

KW - Social reward

UR - http://www.scopus.com/inward/record.url?scp=85033594189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85033594189&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.1834-17.2017

DO - 10.1523/JNEUROSCI.1834-17.2017

M3 - Review article

C2 - 29118215

AN - SCOPUS:85033594189

VL - 37

SP - 10855

EP - 10866

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 45

ER -