Adaptation to the host environment: regulation of the SPI1 type III secretion system in Salmonella enterica serovar Typhimurium

Jeremy R. Ellermeier, James M. Slauch

Research output: Contribution to journalReview article

Abstract

Salmonella enterica invades the intestinal epithelium of the host using a type III secretion system encoded on Salmonella pathogenicity island 1 (SPI1). The bacteria integrate environmental signals from a variety of global regulatory systems to precisely induce transcription of SPI1. The regulatory circuit converges on expression of HilA, which directly regulates transcription of the SPI1 apparatus genes. Transcription of hilA is controlled by a complex feed-forward loop. Regulatory signals feed into the system through post-transcriptional and post-translational control of HilD, which in turn activates HilC and RtsA. These three regulators act in concert to control hilA transcription. The system acts as a switch, ensuring that SPI1 is fully on at the appropriate time.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalCurrent Opinion in Microbiology
Volume10
Issue number1
DOIs
StatePublished - Feb 1 2007

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Genomic Islands
Salmonella enterica
Salmonella
Intestinal Mucosa
Bacteria
Serogroup
Type III Secretion Systems
Genes

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Adaptation to the host environment : regulation of the SPI1 type III secretion system in Salmonella enterica serovar Typhimurium. / Ellermeier, Jeremy R.; Slauch, James M.

In: Current Opinion in Microbiology, Vol. 10, No. 1, 01.02.2007, p. 24-29.

Research output: Contribution to journalReview article

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