TY - JOUR
T1 - Acute hypoxia, diabetes, and neuroimmune dysregulation
T2 - Converging mechanisms in the brain
AU - Johnson, Daniel R.
AU - Sherry, Christina L.
AU - York, Jason M.
AU - Freund, Gregory G.
PY - 2008/6
Y1 - 2008/6
N2 - Acute hypoxia is experienced by a variety of individuals (neonates to the elderly) and in an assortment of conditions and diseases (terrorist bomb attack to decompensated heart failure). Increasingly, elaboration of inflammatory cytokines appears key to the brain-based response to hypoxia, as evidenced by the biobehaviors of malaise, fatigue, lethargy, and loss of interest in the physical and social environment. These sickness symptoms implicate hypoxia-dependent activation of the neuroimmune system as a key component of acute hypoxia. Type 2 diabetes (T2D) is associated with increased incidence, severity, and delayed recovery from hypoxic events. Why T2D negatively affects acute hypoxia is not well understood. Recent work, however, reveals that anti-inflammatory pathways tied to the interleukin (IL)-1β arm of the neuroimmune system may be critical. In this review, the authors examine the link between acute hypoxia, T2D, and neuroimmunity.
AB - Acute hypoxia is experienced by a variety of individuals (neonates to the elderly) and in an assortment of conditions and diseases (terrorist bomb attack to decompensated heart failure). Increasingly, elaboration of inflammatory cytokines appears key to the brain-based response to hypoxia, as evidenced by the biobehaviors of malaise, fatigue, lethargy, and loss of interest in the physical and social environment. These sickness symptoms implicate hypoxia-dependent activation of the neuroimmune system as a key component of acute hypoxia. Type 2 diabetes (T2D) is associated with increased incidence, severity, and delayed recovery from hypoxic events. Why T2D negatively affects acute hypoxia is not well understood. Recent work, however, reveals that anti-inflammatory pathways tied to the interleukin (IL)-1β arm of the neuroimmune system may be critical. In this review, the authors examine the link between acute hypoxia, T2D, and neuroimmunity.
KW - Acute hypoxia
KW - Neuroimmunity
KW - Type 2 diabetes
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U2 - 10.1177/1073858407309544
DO - 10.1177/1073858407309544
M3 - Review article
C2 - 18000066
AN - SCOPUS:43049104517
SN - 1073-8584
VL - 14
SP - 235
EP - 239
JO - Neuroscientist
JF - Neuroscientist
IS - 3
ER -