Acute effect of β amyloid on synchronized spontaneous Ca2+ oscillations in cultured hippocampal networks

Yanfang Rui, Ruxin Li, Yifu Liu, Shaoqing Zhu, Xinzhu Yu, Zhonghua Sheng, Zuoping Xie

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of β amyloid (Aβ) on cytoplasmic Ca2+ ([Ca2+]c) have been studied extensively, but the current literature on this aspect is confusing. We reported that 20 μM Aβ25-35 significantly inhibited the synchronized spontaneous cytoplasmic Ca2+ transients immediately after application, whereas it had little effect on the baseline [Ca2+]c concentration in neurons. Aβ1-42 had a similar effect on the Ca2+ transients as Aβ25-35, while it increased baseline [Ca2+]c concentration gradually. However, Aβ1-40 had little effect on either Ca2+ transients or baseline [Ca2+]c. Such differential effects of Aβ on Ca2+ signals might explain, at least partially, the confusing observations from the previous studies and provide important therapeutic implications for preventing or reversing early neuron damage in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)733-740
Number of pages8
JournalCell Biology International
Volume30
Issue number9
DOIs
StatePublished - Sep 2006
Externally publishedYes

Keywords

  • β Amyloid
  • Ca imaging
  • Ca oscillation
  • Ca transient

ASJC Scopus subject areas

  • Cell Biology

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